IndraLab

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Mutated ATXN3 inhibits autophagy. 2 / 2

| 2

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"Figure 2 (based on [2, 67]) shows how an expansion of the polyQ repeat in mutant ataxin-3, as well as excess polyQ from other cellular (or viral) proteins, could interfere with the interaction of ataxin-3 and beclin-1 to inhibit autophagy."

30182336

➶

reach

"Expression of mutant ataxin-3 also downregulates autophagy through a mechanism related to ataxin-3 DUB activity [64] ."

31079890

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IndraLab

Statements

Mutated ATXN3 inhibits autophagy. 2 / 2

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