IndraLab

Statements

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"Ubiquitin-specific peptidase 2 overexpression inhibited clear cell renal cell carcinoma cell proliferation, migration, and invasion in vitro and in vivo."
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"In contrast, we found that USP2 inhibits the TGF-β signaling and the proliferation of myeloid cells."
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"Inactivation or knockdown of USP2 leads to the degradation of KRAS, resulting in the suppression of MM cell proliferation in vitro and in vivo."
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"USP2a overexpression in HepG2 and Huh 7 cells significantly increased cell proliferation while inhibition of USP2a activity by chemical inhibitor or stable knockout of USP2 by CRISPR markedly reduced cell proliferation."
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"We further found that USP2 inhibits the proliferation of myeloid cells to suppress the activation and expansion of CD4 T cells and CD8 T cells and the production of IL-22 and IFNγ."
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"Taken together, these data suggest that USP2 restricts the proliferation of myeloid cells and thereby inhibits the activation and expansion of IL-22- and IFNγ-producing T cells in the lamina propria during DSS-induced colitis.2.6 USP2 in myeloid cells inhibits immune responses to bacterial infections in the gut."
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"Ubiquitin-specific peptidase 2 inhibited the proliferation, migration, and invasion of clear cell renal cell carcinoma cells."
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"We further revealed that the USP2 stabilizes KRAS by deubiquitination; consequently, USP2 inactivation induced by GA could lead to the destabilization of KRAS, resulting in the suppression of MM cell proliferation in vitro and in vivo."
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"The proliferative abilities shown by the Cell Counting Kit-8 and clone formation assays indicated that cell proliferation was inhibited by ubiquitin-specific peptidase 2 overexpression in all three cell lines (Figures 3(b,c))."
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"These results demonstrate that ubiquitin-specific peptidase 2 inhibited Caki-1 cell proliferation both in vivo and in vitro."
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"These data together suggest that inhibition of USP2 promotes the proliferation of macrophages and dendritic cells to activate IL-22- and IFNγ-producing T cells during DSS-induced colitis.We also examined whether targeting USP2 by ML364 inhibited the dysregulation of ECM and promoted tissue repair."
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"Ubiquitin-specific peptidase 2 inhibition promoted clear cell renal cell carcinoma cell proliferation, migration, and invasion."
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"Knockout or pharmacologic inhibition of USP2 promotes the proliferation of myeloid cells to activate IL-22 and IFNgamma production of T cells."
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