IndraLab

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"Removal of extracellular calcium attenuated induction of hsp70 mRNA but not the induction of c-fos or c-myc."

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"Taken together, our data indicate that Fas and FasL upregulation in AA treated U937 cells is elicited by Ca (2+)/ROS-mediated suppression of ERK and c-Fos pathway and activation of p38 MAPK/ATF-2, and suggest that autocrine Fas mediated apoptotoic mechanism is involved in AA induced cell death."

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"The calcium chelator BAPTA-AM inhibits the shear-induction, as well as the static level, of c-fos activity."

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"Taken together, our data indicate that MMP-2 and MMP-9 down-regulation in caffeine treated U937 cells is elicited by Ca (2+)/ROS-mediated suppression of ERK and c-Fos pathway and activation of p38 MAPK and c-Jun pathway."

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"However, calpains are unable to complete c-Fos degradation (i.e. degradation intermediates accumulate) and, as discussed by the authors [24], the calcium levels used to degrade c-Fos by calpains are h[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"