IndraLab

Statements

Ruthenium red inhibits KCNK2. 3 / 3
| 1 2
sparser
"In the case of TREK channel inhibition by Ruthenium Red, this small positively charged inhibitor is able to access deeper into the exit pathway to block permeation directly above the filter, whereas it may not be possible for this CDR3 loop to insert deep enough to access the keystone Inhibitor site, even if it were longer."
38755204
sparser
"However, ruthenium red inhibits the I110D TREK-1 mutant, which has one isoleucine mutated to aspartate within its extracellular ion pathway xref ."
28851868
reach
"In the case of TREK channel inhibition by Ruthenium Red, this small positively charged inhibitor is able to access deeper into the exit pathway to block permeation directly above the filter, whereas it may not be possible for this CDR3 loop to insert deep enough to access the keystone Inhibitor site, even if it were longer."
38755204