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OTUD5 increases the amount of HNF4A. 4 / 4
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"Meanwhile, overexpression of OTUD5 could inhibit the MAPK pathway and then increase the expression of HNF4a, and ERK1/2 signaling was required for OTUD5-mediated activation of HNF4alpha, promoting HBV replication."
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"Together, these data indicate that OTUD5 could deubiquitinate HBV core protein degradation by its deubiquitinase function and promote HBV activity by up-regulating HNF4alpha expression via inhibition of the ERK1/2 pathway."
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"Another result showed that by activating the ERK1/2 signaling pathway, OTUD5 promoted the expression of HNF4α, a well-known activator of HBV core promoter which can promote the replication of HBV."
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"In this study, we proved OTUD5 could downregulate the expression of phosphorylation ERK1/2 in hepG2.2.15 cells, and the results illustrated that OTUD5 could promote the expression of HNF4α via inhibiting ERK1/2 of MAPK pathway (Fig. 7A–D)."
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