IndraLab

Statements


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reach
"Based on these studies, we propose a model whereby the concerted recruitment of CHMP4B and UBPY to HD-PTP and the engagement of UBPY by STAM2 displaces ESCRT-0 from HD-PTP, deubiquitinates EGFR, and releases ESCRT-0 from cargo in favor of ESCRT-III."

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"Association of UBPY with HD-PTP involves UBPY interacting with HD-PTP-bound CHMP4B, as well as additional interaction (s) between UBPY and HD-PTP."

sparser
"Association of UBPY with HD-PTP involves UBPY interacting with HD-PTP-bound CHMP4B, as well as additional interaction(s) between UBPY and HD-PTP."

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"Hence, like STAM2, UBPY may bind HD-PTP at multiple sites."

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"We investigated in more detail how UBPY bound HD-PTP Bro1-V."