IndraLab

Statements

NEDD4L ubiquitinates SCN5A. 6 / 6
1 2 | 1 2
reach
"Overexpression of NEDD4-2, but not the closely related NEDD4-1, increased Nav1.5 ubiquitination and subsequent degradation in HEK cells."
33093176
ubibrowser
No evidence text available
ubibrowser
"UbiNet 2.0"
15548568
sparser
"Therefore, calcium-mediated increase in NEDD4-2 induced Nav1.5 ubiquitylation with a resultant reduction in Nav1.5 cardiomyocyte membrane density in HF [ xref ]."
34199773
signor
"The control of Nav density at the cell membrane is crucial to ensuring normal neuronal excitability. Navs are subject to posttranslational modifications that may influence their cell membrane availability. Ubiquitylation is a key process that orchestrates the internalization and subsequent degradation or recycling of Navs. This is accomplished by ubiquitin protein ligases, such as NEDD4-2 (neuronal precursor cell expressed developmentally downregulated-4 type 2)."
23778145
sparser
"Follow-up studies identified the ubiquitin-activating enzymes UBE1 and UBA6 ( xref ), as well as the ubiquitin-conjugating enzyme UBC9 ( xref ), to be required for NEDD4-2–dependent ubiquitination of Nav1.5 in neonatal rat cardiomyocytes and HEK cells."
33093176