IndraLab

Statements

NEDD4L leads to the ubiquitination of SCN5A. 3 / 5
1 1 | 1 2
sparser
"Therefore, calcium-mediated increase in NEDD4-2 induced Nav1.5 ubiquitylation with a resultant reduction in Nav1.5 cardiomyocyte membrane density in HF [ xref ]."
34199773
sparser
"Follow-up studies identified the ubiquitin-activating enzymes UBE1 and UBA6 ( xref ), as well as the ubiquitin-conjugating enzyme UBC9 ( xref ), to be required for NEDD4-2–dependent ubiquitination of Nav1.5 in neonatal rat cardiomyocytes and HEK cells."
33093176
reach
"Overexpression of NEDD4-2, but not the closely related NEDD4-1, increased Nav1.5 ubiquitination and subsequent degradation in HEK cells."
33093176