IndraLab

Statements

ARF1 binds OTUB1. 7 / 7
| 7
sparser
"A catalytically inactive version of Otub1, Otub1-ARF1, expressed in Tregs can bind GRAIL and block Otub1 binding, thus allowing USP8 to function as a deubiquitinase to preserve GRAIL expression ( xref )."
41169371
sparser
"Other DUBs, including USP8, Otub1, and Otub1-ARF1, also contribute to Treg regulation and will be discussed in later sections."
41169371
sparser
"IL-2R signaling is maintained through mTOR suppression via Otubain-1 alternative reading frame 1 (Otub1-ARF1) stabilization of GRAIL."
40852720
sparser
"Our unpublished data have demonstrated a marked increase in Otubain1-ARF1 mRNA in Tregs."
36569931
sparser
"Otub1-ARF1 is a catalytically inactive form of Otub1 and competitively inhibits Otub1 by competing for binding to GRAIL and allowing ubiquitinated USP8 to bind to and deubiquitinate GRAIL, thus preserving GRAIL levels ( xref )."
40852720
sparser
"The Fathman lab had previously shown that GRAIL is associated with and regulated by two isoforms of the ubiquitin-specific protease Otubain; Otub1 and Otub1 alternative reading frame 1, (Otub1-ARF1) ( xref )."
36569931
sparser
"In contrast, cells expressing Otub1-ARF1 contained large amounts of endogenous GRAIL, demonstrated diminished functional responses; they proliferated poorly and produced undetectable amounts of IL-2 following antigenic stimulation."
36569931