IndraLab

Statements

KIFC3 binds USP47. 9 / 12
2 | 5 2
biogrid
No evidence text available
25253721
biogrid
No evidence text available
25253721
reach
"Our detailed analysis of the function of the KIFC3 and USP47 complex suggests that it suppresses E-cadherin degradation and internalization."
25253721
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"Double staining for E-cadherin and endogenous KIFC3 or USP47 also showed their overlapping distributions (XREF_FIG), indicating that the KIFC3 and USP47 complex accumulates at the AJs or zonula adherens (ZA), the epithelial form of an AJ."
25253721
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"p120-catenin may serve E-cadherin stabilization by leading the KIFC3 and USP47 complex to these junctions."
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"Of note, the KIFC3 and USP47 complex was detected throughout the cytoplasm."
25253721
sparser
"Here we find that KIFC3 binds the ubiquitin-specific protease USP47, a protease that removes ubiquitin chains from substrates and hence inhibits proteasome-mediated proteolysis, and recruits it to AJs."
25253721
reach
"Thus, the stabilizing role of p120-catenin on E-cadherin might also be explained by its involvement in directing the KIFC3–USP47 complex to adheren junctions [32]."
39833727
sparser
"Thus, the stabilizing role of p120-catenin on E-cadherin might also be explained by its involvement in directing the KIFC3–USP47 complex to adheren junctions [ xref ]."
39833727