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IL1B activates IL1R1. 283 / 286
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"These results demonstrate that the early activation of astrocyte IL-1R1 induced by increased IL-1β controls the development of MA following sciatic nerve injury."
31281242
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"43 Interestingly, IL-1beta up-regulates NGF both in vitro and in vivo, XREF_BIBR, XREF_BIBR and application of IL-1Ra in a TBI rat model suppresses NGF mediated plasticity."
24754437
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"Also, SB-505124, a kinase inhibitor of TGF-β I receptors ALK 4, 5, and 7, inhibited urate induced IL-1β and restored IL-1Ra (Fig. 6B)."
36850003
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"Nor did the kinins affect IL-1beta induced upregulation of IL-1R1."
18467203
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"The other speculation is that IL-33 induces IL-1alpha and IL-1beta (data not shown), and then IL-1alpha and IL-1beta in turn activate IL-1R to induce iNOS in macrophages XREF_BIBR."
24586149
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"Collectively, this work shows that the proinflammatory cytokine IL-1β can directly induce pain by activating a new nociceptive receptor, namely neuronal IL-1R1."
32573694
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"In Q705K-transduced cells, we have found the release of TNF to be a downstream event of IL-1R activation by IL-1β, whereas the increased gene expression of TNF in these cells was not an IL-1R regulated event [ xref ]."
24098386
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"In the CNS, activation of IL-1R1 by IL-1beta activates signaling pathways that modulate intracellular calcium [XREF_BIBR], expression of neurotransmitter receptors [XREF_BIBR], activation of cAMP response element binding (CREB) [XREF_BIBR] and brain derived neurotrophic factor (BDNF) expression [XREF_BIBR]."
22546005
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"The other speculation is that IL-33 induces IL-1α and IL-1β (data not shown), and then IL-1α and IL-1β in turn activate IL-1R to induce iNOS in macrophages xref ."
24586149
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"As expected, IL-1 beta highly stimulated NO, IL-6, IL-8, IL-10, IL-1ra, PGE (2) and stromelysin synthesis, but dramatically decreased PG production."
11069732
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"Moreover, treatment of transformed alphaTC-1 cells with IL-1beta increased IL-1Ra immunoreactivity similar to that observed in transformed INS-1 beta-cells, although alphaTC-1 cells had much lower basal IL-1Ra immunoreactivity as compared to INS-1 beta-cells."
28752047
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"Lung infections are influenced by a balance of pro-inflammatory cytokines, such as TNF-α and IL-1β, which promote inflammation, and anti-inflammatory cytokines, including IL-10, TGF-β, and IL-1ra, which are secreted by alveolar macrophages to mitigate the inflammatory response [24]."
39469699
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"Taken together, these data suggest that the inflammatory airway response to intranasal challenge with Ova initiated by CFA and Ova immunization requires signaling through the IL-1R1 by IL-1alpha but not by IL-1beta."
26978520
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"Primary sensory neurons particularly nociceptors in DRGs express IL-1 receptors (IL-1R), and activation of IL-1R by IL-1β can activate nociceptors rapidly to generate action potentials and elicit pain hypersensitivity via regulating sodium and potassium currents [25, 26]."
28199982
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"In mammals, activation of TLRs on macrophages by microbial molecules trigger production of IL-1β that will activate the IL-1R on neighbour cells, yielding induction of effector molecules."
14751763
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"Also, the effective IL-1beta concentration required to induce IL-1Ra in alphaTC-1 cells was higher than that in INS-1 beta-cells."
28752047
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"This finding suggests that primary human alpha-cells, same as beta-cells, produce IL-1Ra and that elevated IL-1beta levels associated with islet culture and amyloid formation may promote IL-1Ra production in alpha-cells."
28752047
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"For example, previous study showed that the haplotype of IL1B, IL1RN, IL1R1, and IL1R2 increased the risk of venous thrombosis [XREF_BIBR], and IL1 and IL1Ra, CTLA-4 and Apo1 and Fas genes polymorphisms associate with IgA nephropathy [XREF_BIBR]."
28881593
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"This notion is supported by our invitro studies, which showed that IL-1beta can induce IL-1Ra production in both transformed INS-1 beta-cells and alphaTC-1 cells; albeit IL-1Ra immunoreactivity was much lower in alphaTC-1 cells and inducing IL-1Ra production in alphaTC-1 cells required a higher concentration of IL-1beta as compared to INS-1 beta-cells."
28752047
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"Whereas pro-IL-1β fails to trigger IL-1 receptor (IL-1R) activation, mature IL-1β, upon release from the cell, triggers pleiotropic downstream effects, establishing an inflammatory state."
37578727
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"Among the various cytokines produced by cells, IL-6 is known to be a multifunctional cytokine that can be produced by IL-1β–IL-1R signaling, and is very important for the prevention or treatment of skin aging [23]."
29932110
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"Upon activation, mature secreted IL-1β binds to and activates IL-1R1 on cell surfaces (such as immune and cancer cells) in an autocrine or paracrine manner [ 18 ]."
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"IL-1β also activates IL-1R to contribute to hyperalgesia and the establishment of peripheral and central sensitization [ xref , xref ]."
28359290
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"The main signaling pathway induced by the binding of IL-1β onto IL-1 receptor type 1 (IL-1r1) leads to NFκB activation which will in turn increase inflammation [6,8] ."
18511291
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"IL-1beta increased lipid droplet and triglyceride content in WT and TLR9 -/- -cultured hepatocytes, but not IL-1R -/- hepatocytes (XREF_FIG)."
20347818
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"The greater IL-1beta content in the hypothalamus compared with frontal cortex as early as 1 h after MDMA injection could trigger the release of IL-1ra in an attempt to limit the effects of the released IL-1beta."
21595923
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"To determine whether the dramatic decrease in CB2-mRNA level, observed only under LPS treatment, was due to strong activation of IL-1R by IL-1β, BV2 cells were incubated with IL-1RA (1–1000 ng/mL), the natural IL-1R antagonist, 30-min prior to and during LPS."
39160534
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"IL-1RA production in hepatocytes is stimulated by IL-1beta and interferon, inflammation stimulates myeloid cells production of IL-1RA, and IL-1RA can arise from macrophages induced by IL-6."
24273017
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"IL-1R is activated by IL-1β, elicits signal transduction, leads to the transcription of IL-8 gene."
38608448
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"AT derived IL-1beta acts in an autocrine or paracrine fashion to contribute to obese AT inflammation and dysfunction, and accordingly, ablation of IL-1beta signaling in IL-1R knockout mice attenuated the HFD induced AT and systemic IR [XREF_BIBR]."
29186929
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"Our in vivo study showed that prevention of IL-1beta maturation in Casp-1 -/- and Nalp3 -/- mice or of IL-1beta signaling in Il1r -/- mice reduced circulating sTNFR1 concentrations after CLP."
25628461
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"The endogenous pro-inflammatory cytokine IL-1β activates IL-1R/MyD88 signaling, thus impairing MSC proliferation, migration and differentiation by inhibiting the AKT/GSK-3β/β-catenin pathway (30)."
34278470
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"Because IL-1beta has been reported to trigger the IL-1R1 signaling pathway, which activates signaling proteins, such as mitogen activated kinases (c-Jun N-terminal kinase (JNK), p38, extracellular signal regulated kinase (ERK)) and transcription factors (nuclear factor (NF)-kappaB) 35, we analyzed the effects of NF-kappaB inhibitor (Bay11-7082) and p38 inhibitor (SB203580) treatment."
30755603
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"In patient samples, IL-1beta promotes expansion of AML progenitor cells as well as growth and survival of AML cells, and IL1R1 null mice have improved survival relative to WT in an AML model [XREF_BIBR]."
30279971
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"IL-1β activation of neuronal IL-1R1 induces Src kinase-mediated tyrosine phosphorylation of the NR2B subunit of the NMDA receptor."
18495419
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"The TLRs recognise conserved molecules derived from bacteria, fungi and viruses and contribute towards the innate immune response whilst the IL-1Rs are activated by the pro-inflammatory cytokines, IL-1α, IL-1β, IL-18 and IL-33 [ xref ]."
20525168
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"Cultures with NF-κB-IL-1Ra macrophages produced significantly higher levels of IL-1Ra than non-transduced macrophage co-cultures, producing 100 pg of IL-1Ra per 10 macrophages in co-culture by 48 hours in response to both 0 and 1 ng/mL of IL-1β."
38854124
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"Thus, IL-1 receptor (IL-1R) signaling is indispensable for clearance of bacteria and survival in our infection model.IL-1R1 is a subunit of the IL-1R, which is activated by the closely related but fun[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26962946
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"Interestingly, IL-1β-induced IL-1R downstream signaling activation was ablated in IRAK4 KI cells, as IRAK1 degradation, induction of c-Jun N-terminal kinases (JNK) and IκBα phosphorylation were diminished in IRAK4 KI cells compared to WT cells ( xref )."
32682051
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"The signaling components in the NF-κB pathway downstream of IL-1β-induced activation of IL-1R are well characterized."
23143332
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"IL-1R is activated by both IL-1α and IL-1β, which have unique and shared functions (Dinarello, 2018)."
38363547
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"However, in response to seizures, IL-1β may induce the synthesis of IL-1Ra which, in turn, reduces the pro-inflammatory effects of IL-1β."
40012256
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"Schauer et al. presented findings indicating that a high level of IL-1β in ovarian cancer stimulates IL-1R1 on adjacent CAFs, leading to the inhibition of P53 and transactivation of the NF-κB signaling pathway in CAFs [165]."
38649701
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"The results show that young IL-1β ko and IL-1r1ko mice showed an impairment in spatial memory task learning in the WM, suggesting that brain IL-1β activates IL-1r1 to facilitate hippocampal spatial learning and memory in young mice (Figures xref , xref )."
29123474
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"IL-1R1 is activated by IL-1beta that is released from neurons , glia , brain endothelial cells , and infiltrating monocytes following inflammasome activation ( Labzin et al ., 2016 ; Vezzani et al ., 2019 ) ."
35615063
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"As shown in XREF_TABLE, IL-6 and CXCL1 were detectable at very low levels in WT mice treated with saline or in IL-1R1 -/- mice treated with IL-1beta but these molecules were robustly expressed in WT mice treated with IL-1beta."
24205219
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"Activation of IL-1R1 by IL-1β may result in PLC generation, leading to the production of DAG."
34143493
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"The induction of IL-1Ra by IL-1beta is an important counterregulatory mechanism and may at least partially account for the increased IL-1Ra levels found in the carriers of allele II [XREF_BIBR, XREF_BIBR]."
23049596
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"Western blotting demonstrated that TOGA attenuated the upregulation of IL-1R1 induced by IL-1β."
33031908
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"There are NF-κB binding sites upstream of the IL-1Ra promoter ; IL-1Ra is reported to be upregulated by IL-1β in endometrial stromal cells ; the expression of IL1Ra follows the expression of IL-1β when induced by LPS in Schwann cells , and both are upregulated in response to leptin in β-cells."
39266581
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"36 However, the detection of IL1R1 immunoreactivity on epithelial basal cells and neuroendocrine cells of the trachea and on blood vessels in the brain and heart, which are known to respond to IL-1bet[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23391392
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"IL-1β activates interleukin-1 receptor (IL-1R), leading to IKKβ activation, thereby phosphorylating IκBα."
26976669
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"Others have shown that IL-1R1 receptor activation by IL-1β increases the excitability of cultured neurons isolated from DRG, including via actions on voltage-gated sodium ion channels and potassium channels xref , xref , xref – xref ."
38643253
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"RA at a concentration of 0.01-1 muM resulted in a concentration dependent enhancement of PMA induced IL-1 beta production and a concentration dependent inhibition of PMA induced IL-1ra production and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9783809
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"In the context of senescence, this regulation was a consequence of IL-1R signaling specifically activated by IL-1alpha but not IL-1beta."
20148189
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"For the placenta, IL-1α and IL-1β induced a significant increase in IL-1Ra ( Fig. 5 A) and IL-18 an increase in IL-18BPa ( Fig. 5 B); there were no other effects seen."
28712670
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"Activation of IL-1R by IL-1beta in astrocytes, decreases glutamate reuptake and simultaneously stimulates the release of glutamate from astroglial cells via TNFalpha induction, mediated through activation of TNFalphaR [XREF_BIBR]."
29928494
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"According to this alternative assumption, activation of glial IL-1R1 by IL-1β leads to the release of gliotransmitters which may amplify glutamatergic synaptic transmission."
28645297
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"IL1R is activated by IL1β, a known sleep regulatory molecule [ xref , xref , xref , xref , xref ]."
22387068
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"Although the IL-1R1 and TNFRII, but not TNFRI, were up-regulated by IL-1beta and TNF-alpha, none of these receptors were regulated, at the mRNA level, by kinin receptor subtypes, neither in the absenc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18467203
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"For the choriodecidua IL-1α, IL-1β and IL-18 induced a significant increase in IL-1Ra ( Fig. 5 E), IL-1α, IL-1β a significant increase in IL-18BPa ( Fig. 5 F), IL-1α, IL-1β and IL-33 a significant inc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28712670
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"IL-1R is activated by its ligands IL-1alpha and IL-1beta [XREF_BIBR; XREF_BIBR]."
22137885
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"IL-1beta induces IL-1Ra production; thus, upregulated IL-1Ra levels are considered to reflect higher IL-1beta activity [XREF_BIBR] and predispose to insulin resistance and type 2 diabetes [XREF_BIBR]."
30094409
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"The elevated basal levels of IL-1ra in the aged may occur in reaction to the basal elevations of IL-1beta, as IL-1beta can initiate the release of IL-1ra along with several other molecules."
27916728
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"Elevation of IL-1beta induces a robust release of other pro inflammatory cytokines including IL-6 and IL-8, as well as its competitive antagonist IL-1RA (interleukin-1 receptor antagonist) a potent anticonvulsant XREF_BIBR, XREF_BIBR."
28448686
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"These variants typically lead to the loss of IL-1Ra production, the endogenous inhibitor of the proinflammatory cytokines IL-1α and IL-1β (3, 4)."
38646532
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"IL-1 encompasses two distinct cytokines, IL-1-α and IL-1β, that signal via IL-1R."
38251210
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"In contrast, neutralizing antibodies against IL-1beta did not suppress inflammatory cytokine secretion, suggesting that IL-1beta secretion levels at senescence are not sufficient to produce a significant level of IL-1R signaling."
20148189
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"One mechanism for the initiation of IL-1β-induced fever is that circulating IL-1β activates IL-1R1 in endothelial cells, which produce (Cao et al., 1996, Konsman et al., 2004)."
35429606
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"In addition, the Fas mediated IL-1beta production was required for Th17 and Th1 induction during bacterial infection : Th17 and Th1 induction was abolished in Fas -/- mice, whereas supplementation with recombinant IL-1beta restored Th17 and Th1 induction via IL-1 receptor 1 (IL-1R1), and rescued the mortality of Fas -/- mice infected with Listeria IL-1R1, but not apoptosis associated speck like protein containing a caspase recruitment domain or Fas on T cells, was required for Th17 and Th1 induction, indicating that IL-1beta stimulates IL-1R1 on T cells for Th17 and Th1 induction."
28674179
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"Our results show that IL1b induced IL-1Ra production was significantly enhanced when 1400W, a highly selective inhibitor of iNOS (45), was added into the culture."
12635941
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"The results show that chronic icy microinfusion of IL-1 beta induced significant anorexia, increased the cerebellar IL-1RI mRNA content, increased IL-1Ra and IL-1 beta mRNAs levels in the cerebellum> midbrain> cortex> hippocampus, and induced profiles of IL-1RI mRNA, IL-1Ra mRNA, and IL-1 beta mRNA that were highly intercorrelated."
8906613
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"During the response to seizures, the IL-1beta system induces IL-1Ra, which acts by limiting IL-1beta-mediated pro inflammatory actions."
29017522
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"IL-1R is activated by both IL-1α and IL-1β, which have unique and shared functions ( xref )."
38363547
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"In cisplatin-induced nephrotoxicity, increased expression of IL-1β was detected, which triggered the activation of IL-1R, inducing TNF-α production and leading to AKI, suggesting that knocking out IL-1 receptor holds the potential of decreasing cisplatin-induced acute kidney injury [57]."
36552226
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"The family contains IL-1alpha and IL-1beta, which both activate the same receptor, IL-1R, [XREF_BIBR] and IL-18 which activates the IL-18R [XREF_BIBR], [XREF_BIBR]."
25085021
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"Although both IL-1α and IL-1β activate IL-1R1, we initially focused on the role of IL-1β."
37060806
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"IL-1R1 ( Figure 5 A, panel 9) was also up-regulated by recombinant IL-1β relative to control (6.5- ± 0.1-fold, P < 0.01), and this was attenuated by SP."
37164275
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"A HEK-Blue IL-1β reporter assay that measures NF-κB-mediated secreted embryonic alkaline phosphatase release after IL-1R1 activation by IL-1β was used to measure the activity of IL-1 at neutral and acidic pH."
26324708
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"IL-1Ra production is induced by IL-1beta and, thus, is acting as a counter-regulator of IL-1beta mediated processes [8-10]."
29395365
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"This is mediated by IL-1beta activation of IL-1R and MyD88 signaling, which triggers NF-kappaB and other signaling molecules that induce proinflammatory mediators and chemokines to promote neutrophil trafficking from the circulation into the infected tissue XREF_BIBR."
23209417
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"This phenomenon was more prominent in BMMs isolated from matured adult mice, as IL-1β, TNF-α, and IFN-γ together led to an around 20-fold increase in the expression of IL-1R1, while IL-1β alone only upregulated IL-1R1 by fivefold."
35534483
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"Collectively, this data strongly suggests that IL-1α (and maybe even IL-1β which also signals via IL-1R1) and perhaps IL-33 via the activation of IL-1R1+ ILC2s and ST2+ ILC2s, respectively, work to initiate sensitization to PN via the airways."
38314333
eidos
"Activation of IL-1R1 by IL-1beta may result in PLC generation ,13 leading to the production of DAG ."
34143493
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"The up-regulation of IL-1R1 signaling caused by IL-1β can promote the pyroptosis of alveolar macrophages and aggravate lung injury (100)."
38035100
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"In our experiments, 1pg/ml of IL-1beta stimulated production of IL-1R and ADAMTS4 in combination with 40kPa of cyclic compressive loading, because excessive mechanical stress substantially induced IL-1R in 3D cultured ATDC5 cells."
33648469
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"Accordingly, the eleven uniquely DE genes in the IL-1β vs IL-1β + IL1Ra comparison and the three genes DE across all treatments (MIP-2BETA, GPR84 and GLCCI1; Fig. 6A) are unlikely to be mediating the functional rescue of IL1Ra on collagen gel contraction."
37314623
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"Similarly, IL-1R1 gets activated during epilepsy by interleukin-1β (IL-1β), which is released from neurons, glial cells, brain endothelium, and macrophages that have been extravasated in the brain from the blood (16, 17)."
34354662
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"Moreover, exercise training increased WBC and lymphocytes numbers at 6 h after LPS exposure (Supplementary Fig. 3f–i), reduced serum levels of the pro-inflammatory cytokines including TNF, IL-1β and TIMP-1, increased the anti-inflammatory cytokine IL-1Ra (Supplementary Fig. 3j–m), mitigated liver, lung and spleen injury caused by LPS challenge (Supplementary Fig. 3n–p)."
38600123
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"Though IL-1B increased Il1r1 mRNA in the total lung of wild type mice, we did not see a corresponding increase in the percentage of granulocytes in the BAL."
38173934
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"XREF_BIBR, XREF_BIBR Furthermore, the monocyte expansion observed with dexamethasone treatment could be explained by its ability to mimic IL1B activation of IL1R, 42 which stimulates their proliferation."
31439679
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"IL-1R is activated by its ligands IL-1α and IL-1β [ xref ; xref ]."
22137885
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"This observation is consistent with reports that IL-1beta is a potential inducer of IL-1ra, and suggests a feedback mechanism of IL-1 activity."
9565638
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"Together, the similar kinetics of PGE production, PG profiles and the induction of mPGES-1/COX-2 axis suggest that IL-1β /HMGB1 complexes mediate their effects on the prostanoid cascade through the same pathway as IL-1β, via the IL-1RI receptor.Further, we studied whether the induction of the PGE synthesis cascade and the cytokine response by IL-1β /HMGB1 complexes were mediated via IL-1RI using the IL-1Ra."
23488692
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"IL-1β activates IL-1r on lamina 1 neurons and modulates function of postsynaptic NMDA receptors such that Ca2+ influx is increased when they are activated by glutamate."
35295524
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"Since IL-1Ra does not activate IL-1 receptor cell signaling cascades and IL-1Ra production can be induced by IL-1beta and/or IL-1alpha, it is plausible that the increased IL-1Ra in the ascites and the associated poor prognosis is due to secreted IL-1beta signaling [XREF_BIBR]."
21765834
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"However, IL-1beta alone could not induce IL-17 production in Il1rn -/- gammadelta T cells, even though these cells expressed IL-1R, consistent with a report that IL-1beta alone does not induce IL-17 in peritoneum- and lung derived gammadelta T cells expressing high levels of IL-1R XREF_BIBR."
26108163
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"IL-1β and HMGB1 significantly reduce human hippocampal neurogenesis and blockade of their IL-1R and TLR 2/4 receptors by IL1Ra and Box-A respectively, significantly restores neurogenesis in 2D and 3D culture."
34548070
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"By contrast, IL-1R is activated by IL-1α and IL-1β, which are produced by host cells xref ."
21720387
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"A human experiment has shown that IL-1beta induces the secretion of IL-1ra, and that induction of IL-1beta precedes secretion of IL-1ra."
19125204
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"IL-1β up-regulates IL-1RA synthesis under conditions of inflammation but it also augments its own production and the expression of proinflammatory genes including IL-8 by the human vaginal and cervica[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21530305
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"In addition, excessive IL-1beta production and degranulation of leukocytes stimulate IL-1RA production, causing the IL-1beta and IL1RA ratio to decrease and the IL-8 production to fade."
10764465
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"Suppression of Mtb replication was a specific action of IL-1beta, since neither Tim3-Ig nor IL-1beta were able to inhibit bacterial growth in infected Mphi lacking IL-1R (XREF_FIG)."
23487424
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"In chondrocytes, IFNbeta alone had no effect, but dose dependently enhanced the secretion of IL1Ra induced by IL1beta."
14672890
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"The antagonistic receptor of IL-1 β (IL-1ra) is initially activated by IL-1β, which initiates an intracellular cascade of biochemical events."
18442781
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"The IL-1R can also be triggered by IL-1β, whose release often depends on the Nlrp3 inflammasome."
26200011
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"IL-1R is activated by IL-1β."
34040600
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"Because IL-1beta has been shown to increase IL-1ra secretion, we next investigated if there were any correlations between O 3 -induced changes in IL-1beta and IL-1ra."
25959670
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"We found that the IL1RA and IL-1beta balance in dM supernatants in both basal and TLR stimulated conditions always favored IL-1RA."
25071732
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"The extracellular IL-1β and IL-18 can induce a strong inflammatory response by activating the IL-1R/IL-18R-MyD88-NFκB pathway."
36551161
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"By inhibiting the β-catenin pathway via IL-1R1/Myeloid Differentiation primary response 88 (MyD88) signaling, IL-1β impaired the capabilities of osteogenic differentiation, migration, and proliferation of stem cells (21)."
40279432
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"We also show that P. aeruginosa activates NF-κB in macrophages through both the TIR-containing adaptor protein (TIRAP)/MyD88 dependent and the TRIF-dependent pathways, and that IL-1α and IL-1β activation of IL-1R1 is an important feedback pathway in the host response to P. aeruginosa."
20826748
eidos
"Although both IL-1alpha and IL-1beta activate IL-1R1 , we initially focused on the role of IL-1beta ."
37060806
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"Therefore, without functional IL-1 receptor on glutamatergic neurons, the IL-1β released by inflammatory monocytes, microglia, or other cells after acute defeat in stress-sensitized mice cannot activate IL-1R1 in neurons."
36388133
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"Although both IL-1alpha and IL-1beta can activate IL-1R and MyD88 signaling, their cellular source and post-translational processing are different [XREF_BIBR]."
22057887
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"Rather than involvement of different DC subsets, the lower percentage of antigen-specific Tregs in response to S. aureus could be explained by heightened Il-1β-dependent activation of IL-1R1 in response to the virulence factor alpha-toxin."
31784259
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"Eventually, NALP3-mediated secretion of IL-1β may induce IL-1R1/MyD88-dependent proinflammatory responses."
18191460
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"Diabetic wounds produce various inflammatory factors and chemotactic factors in the wound microenvironment, such as AGE, MCP-1, DAMPs, and IL-1β, which mutually induce the NLRP3 and IL-1R1 signaling pathways."
38613800
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"We thus propose that the presence of IL-1alpha or IL-1beta is sufficient to trigger IL-1R pathway, an essential component in the development of innate response to acute M. tuberculosis infection, but may not be sufficient for full control of the infection."
25400917
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"Taken together, these data show that either IL-1α or IL-1β can activate IL-1R1 in P. aeruginosa keratitis and that IL-1R1 has an essential role in regulating the inflammatory response to P. aeruginosa in the cornea."
20826748
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"The sensing of L. pneumophila flagellin by NAIP5 activates NLRC4 inflammasome, induces caspase-1 cleavage, and IL-1β secretion which activates IL-1R signaling and drives the development of Th17 cells [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30739833
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"Additionally, IL-1β also activates IL-1R1 on nociceptor neurons to increase TRPV1 expression for pain sensitivity and neurogenic inflammation ( Ebbinghaus et al., 2012 )."
35728484
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"As they signal via the same receptor, release of IL-1α alongside IL-1β during inflammasome activation may supplement IL-1R activation by IL-1β."
29247991
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"In subcultured de-differentiated chondrocytes, A77 1726 exhibited a marked dose dependent effect on IL-1beta induced IL-1Ra production, which was greatest at 100 mumol/l."
15142263
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"In freshly isolated primary chondrocytes, A77 1726 used at 100 mumol/l also enhanced secretion of IL-1Ra induced by IL-1beta."
15142263
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"We next investigated whether the stimulatory effect of A77 1726 was restricted to IL-1Ra production induced by IL-1beta, or whether it could also be observed in the presence of other proinflammatory cytokines, such as TNF-alpha."
15142263
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"Following TLR induced NF-kappaB activation, pro inflammatory IRI signature, i.e., TNF-alpha, IL-1beta, IL-6 are essential to promote TNFR and IL-1R de novo activation."
25066922
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"IL-1β release is highly inflammatory, and activates IL-1R1 and via the production of chemokines, causes neutrophil recruitment ( Sadik et al., 2011 ; Miller et al., 2006 )."
38565393
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"Thus, CCL-18 could act as an endogenous inhibitor of GPER, similar to the actions of IL-1ra, which attenuates the activation of IL-1R by IL-1β ( xref )."
24530924
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"Constitutively activated NLRP3 in melanoma secretes IL-1β that initiates IL-6 secretion through stimulating IL-1R [202]."
36932407
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"IL-1β also activates IL-1R1 on nociceptor neurons to increase TRPV1 expression and, consequently, pain sensitivity to thermal stimuli [ xref ]."
27793571
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"As a central pro inflammatory mediator, IL-1beta leads to the activation of IL-1R1 and MyD88 signalling pathways, which induces the activation of transcription factor NF-kB."
27306439
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"Activation of IL-1R by IL-1β in astrocytes, decreases glutamate reuptake and simultaneously stimulates the release of glutamate from astroglial cells via TNFα induction, mediated through activation of TNFαR [ xref ]."
29928494
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"IL-1RA is an endogenous inhibitor of IL-1R1 ( xref ). xref suggested that IL-1β activates IL-1R1 on neurons and induces tyrosine phosphorylation of the NR2B subunit of NMDA receptor through Src kinase, leading to increased NMDA receptor-mediated calcium influx, thereby enhancing neuronal excitability."
35720723
sparser
"IL-1R activation by IL-1β can also promote glutamate release from the astrocytes [ xref , xref ]."
34571003
reach
"Two distinct cytokines, IL-1alpha and IL-1beta, can stimulate the IL-1R."
23686480
reach
"Gaofeng, Wang, et al. revealed that Staphylococcus aureus, which is always considered a pathogenic bacterium, stimulates hair follicle regeneration via activating the IL1R/Myd88 pathway by IL-1β secre[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37068658
reach
"After IL-1β stimulates chondrocytes to bind IL-1R, the NF-κB pathway is activated and chondrocytes secrete IL-6 and act on IL-6R, upregulating STAT3 expression to promote IL-6 secretion by macrophages, thus promoting IL-6 and IL-8 re-release (97)."
38590580
reach
"Specifically, IL-1β, SDF1α, and VEGF activate G-protein-coupled receptors (GPCRs), receptor tyrosine kinases (RTKs), and TLR/IL-1R, leading to activation of Ras and its downstream target phosphoinositide 3-kinase γ (PI3Kγ), the PI3K isoform predominantly expressed in myeloid cells ."
35879449
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"Combining these previous studies with the present findings, a host defense pathway has been discovered whereby neutrophils represent a source of IL-1β, which subsequently activates IL-1R expressed on non-bone marrow-derived resident skin cells to promote effective neutrophil recruitment in host defense during a S. aureus skin infection."
23209417
reach
"The positive impact of IL-1β on host resistance to Mtb infections in the mouse model is well supported by several studies using Il1r1 and Il1b knock-out mouse strains [3,4,6,26]."
34324582
reach
"CFA-induced inflammatory orofacial hyperalgesia produces an increase in IL-1β activation of IL-1R in the ipsilateral Vi/Vc."
23092240
sparser
"IL-1α and IL-1β are two major cytokines able to activate IL-1R, and both of them may be released by stressed cells."
24172847
reach
"In particular, IL-1β, SDF1α, and VEGF in the TME activate G-protein coupled receptors (GPCRs), receptor tyrosine kinases (RTKs), and TLR/IL-1R, thereby activating Ras and its downstream target PI3Kγ [68]."
38185636
reach
"Compared with controls, asymptomatic patients had increased production of IL-1beta and IL-12 (both P < 0.05), unchanged production of TNF-alpha, IFN-gamma and IL-1ra and notably reduced production of IL-10, IL-2 and sIL2-ralpha (all P < 0.05)."
12598772
reach
"IL-1 beta was shown to induce a rapid and strong synthesis of IL-6 and IL-1ra in the pituitary but failed to regulate GH contents or release."
12588520
sparser
"The pathway involves activation of IL-1R by IL-1β and further recruitment of MyD88."
35139823
reach
"In contrast, in a S. aureus osteomyelitis model, both IL-1β and IL-1α contributed to the IL-1R/MyD88-mediated host defense , suggesting that the anatomical location of the S. aureus infection and the presence of the orthopaedic implant likely contributed to the more predominant host defense role of IL-1β rather than IL-1α."
31975434
reach
"Microbial products and cytokines interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) acts as primary stimuli and initiates inflammation through interacting with the toll like receptors (TLR)s, IL-1 receptor (IL-1R), IL-6 receptor (IL-6R), and the TNF receptor (TNFR) reported by Kaminska in 2005 (Kaminska, 2005)."
| PMC
reach
"Then, cooperation between HIF-1α and GPER will promote the expression of IL-1β, which in return will activate the IL-1R signaling pathway."
36499246
reach
"Haplotype ' T-E1-2 ' was increased in RE which is associated with high production of IL-1beta and low production of IL-1Ra and haplotype ' C-E2-1 ' that is associated with low production of IL-1beta a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16635751
reach
"In response to seizures, the IL-1beta system induces IL-1Ra, which acts by limiting IL-1beta-mediated proinflammatory actions XREF_BIBR."
23908665
reach
"Because IL-1RA inhibits the activities of IL-1β, IL-1RA is generally increased by IL-1β and is therefore usually considered to be a surrogate marker of IL-1β concentration (Bartfai et al., 2007)."
33234171
reach
"Additional treatment with conditioned media from SF-UC-MSCs downregulated their gene expression by 0.25-fold, 0.71-fold, 0.80-fold, and 0.29-fold, respectively.With respect to anti-inflammatory cytokines, IL-1β significantly downregulated the gene expressions of IL-4 by 0.48-fold; however, IL-1β upregulated those of IL-10 and IL-1ra by 1.4-fold and 211.1-fold (Figure 3D), respectively."
39534392
sparser
"Additionally, recent work has shown that IL1β activation of IL1R1 on astrocytes specifically represses IL-1-induced inflammatory cytokine expression in microglia [ xref ]."
31170999
reach
"IL-1β also activates IL-1R to contribute to hyperalgesia and the establishment of peripheral and central sensitization [28, 46]."
28359290
reach
"Human gastric cancer cell lines (MKN7, MKN74, and TMK-1) with and without pretreatment of IL-1 receptor antagonist (IL-1ra) were treated with IL-1beta or infected with H. pylori."
22415887
sparser
"To determine whether the dramatic decrease in CB2-mRNA level, observed only under LPS treatment, was due to strong activation of IL-1R by IL-1β, BV2 cells were incubated with IL-1RA (1–1000 ng/mL), the natural IL-1R antagonist, 30-min prior to and during LPS."
39160534
reach
"On the other hand, IL-1β has been reported to upregulate IL-1R through the PI3K/AKT signaling pathway [95] , which is attenuated by metformin in primary cultured rat hepatocytes [96] ."
35134385
reach
"IL1B up-regulated both the signaling IL1R1 and the inhibitory IL1R2, while adding hCG further increased IL1R1 and significantly downregulated IL1R2."
23351058
reach
"However, IL-1 alpha and IL-1 beta were better inducers of IL-1ra than was TNF-alpha."
8179914
reach
"These include CXCL1/KC, which recruits neutrophils from limbal capillaries to the corneal stroma, and IL-1α and IL-1β, which then activate the IL-1R1 /MyD88 pathway in macrophages and resident corneal epithelial cells and keratocytes [40]."
23360155
reach
"IL-1 alpha or IL-1 beta at a dose of 10 ng/ml induced 3 to 6 ng/ml of IL-1ra, while TNF-alpha at a dose of 100 ng/ml stimulated only 1.4 ng/ml of IL-1ra."
8179914
sparser
"Activation of IL-1R1 by IL-1β may result in PLC generation, xref leading to the production of DAG."
34143493
reach
"Elevated levels of IL-1β lead to IL-1R/IRAK1–dependent activation of synovial fibroblasts to secrete CXCL1/5 and recruit more neutrophils."
35801586
reach
"Furthermore, for IL-1 beta induced IL-1ra, immunoprecipitation of IL-1 beta with an anti-IL-1 beta antibody, but not a preimmune antibody, blocked the induction of IL-1ra."
8179914
reach
"As described earlier, the TLR4/IL-1R signaling pathway that produces IL-1β is upregulated on mast cells and macrophages in males and is key in initiating myocarditis/pericarditis in animal models."
37167363
reach
"In contrast to mononuclear phagocytes, IL-1 alpha, IL-1 beta, and TNF-alpha did not induce further IL-1ra production in alveolar macrophages."
8179914
reach
"Meanwhile, it was remarkable that cartilages from wild-type mice could not produce active IL-1β, which is consistent with the limited efficacy of IL-1β inhibitors in OA treatment.The antidepressant am[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37992880
sparser
"IL-1R can be activated by IL-1α and IL-1β within the inflamed comedones of acne patients [ xref ]."
38731983
reach
"Wang et al. demonstrated that IL-1β and TNF-α secreted by the T2DM islet could stimulate MSCs to secrete IL-1Ra, which could ameliorate islet inflammation (Figure 2) [37]."
36045953
sparser
"In addition, we now show that IL-1R activation by IL-1β induces the IL-1α gene in pancreatic β-cells ( xref C–G), suggesting a cytokine ‘circuit’ that promotes overall β-cell health ( xref G)."
33285301
sparser
"Nonetheless, as both IL-1α and IL-1β activate IL-1Rs, these studies support the concept that activation of IL-1Rs regulate the expression and activity of hippocampal SERTs."
34010713
reach
"In turn, IL-1β induces IL-6 synthesis, as well as the production of IL-1Ra, a natural endogenous inhibitor of IL-1."
39882243
reach
"IL-1beta markedly stimulated the induction of IL-1R1, which preceded the induction of iNOS."
15030977
reach
"The pHEMA particles were then used in an in vitro setting with IL1Ra, and it was demonstrated that cells treated with IL1beta and exposed to IL1Ra nanoparticles maintained NF-kappaB expression levels similar to those of unstimulated controls, demonstrating protection [XREF_BIBR]."
28455189
sparser
"In response to IL-1β, U251 and U87MG GB cell lines secreted more IL-1β and the high IL-1β conditioned media of U87MG promotes angiogenesis and neurotoxicity in human umbilical vein endothelial cells and neurons, respectively. xref It was reported that IL-1β stimulation increased IL-8 and CCL2 secretion in the U251 GB cell line, suggesting monocyte-neutrophil recruitment and proangiogenic environment ( xref ). xref Additionally, a report in a mouse model of GB has shown that monocyte infiltration in TM produces more IL-1β activating IL-1R in GB cells, inducing an interplay between GB and monocytes that promotes tumor progression. xref These reports suggest a crucial circuit between GB and immune cells via IL-1β."
40351835
sparser
"For example, IL-1β activation of neuronal IL-1R1 induces within 5 min the hydrolysis of membrane phospholipids, including ceramide, as well as protein phosphorylation."
25445483
reach
"IL-1beta stimulates the release of IL-1Ra which antagonizes IL-1beta binding to the cell receptors [XREF_BIBR, XREF_BIBR]."
19707530
sparser
"IL-1R, which also functions through MyD88, is activated by the pro-inflammatory cytokines IL-1β and IL-18 and contributes to retinal degeneration ( xref ; xref )."
25725353
reach
"The regulation of IL-1ra in somatotroph adenoma cells is different from human cultured monocytes, in which IL-1 beta significantly stimulated IL-1ra secretion into the culture supernatants, and no change of intracellular IL-1ra content was observed."
9661623
sparser
"CFA-induced inflammatory orofacial hyperalgesia produces an increase in IL-1β activation of IL-1R in the ipsilateral Vi/Vc."
23092240
sparser
"We demonstrate that activation of IL1R1 by IL-1β (or IL-1α) may carry an important activation signal for innate immune responses, with the example of antimicrobial peptide production (Figure xref )."
21261944
sparser
"We found that the inhibition of gamma-secretase significantly reduced COX-2 upregulation in MSCs in response to IL-1R activation by IL-1β."
25266361
reach
"Bacteria activate inflammasome pathways and induce IL-1β secretion, which further triggers IL-1R signaling and promotes Th17 cell differentiation, conferring protective immune responses."
30739833
sparser
"IL-1R1 receptor activation by IL-1α and/or IL-1β induces an array of factors including IL-1, IL-6 (CXCL6), IL-8 (CXCL8), interferon (IFN) α, β, and γ, defensins, matrix metalloproteinases (MMPs), C-reactive protein, etc ( xref , xref , xref )."
31788049
reach
"IL-1 beta induced production of both IL-1Ra and IL-1 alpha at each time point and concentration tested."
7485466
reach
"A major branch of the innate immune system is regulated by the Toll like receptors (TLRs), which are receptors for endogenous damage associated molecules released from injured cells as well as pathogen derived molecules, and interleukin-1 receptors (IL-1R), which are activated by IL-1alpha, IL-1beta and IL-18 cytokines."
25725353
reach
"Culture conditions of PBMC influenced the production of IL-1ra but not IL-1 beta."
1831680
reach
"Moreover, neutrophils, upon the onset of nod-like receptor protein (NLRP)3 inflammasome activation, by means of IL-1β secretion (3, 9) upregulate IL-1R in cardiac fibroblasts, in order to induce apoptosis, inflammation, and fibrosis."
35711341
reach
"Indeed, IL1R1 can be activated by both IL-1B and IL-1A."
34290237
reach
"IL-1RA, an anti-inflammatory cytokine, is induced by IL-1beta and blocks the pro inflammatory cytokine action of IL-1beta at IL-1 receptor I. IL-1RA can be easily measured compare with IL-1beta, and systemic levels of IL-1RA are elevated in obesity, insulin resistance and type 2 diabetes patients."
29277966
sparser
"Some examples of DAMPs include the danger signal HMGB1, a highly motile non-histone nuclear protein, as well as other molecular patterns associated with danger, such as IL-1β activating IL-1R1, and TLR4."
39006715
reach
"In addition, it has been shown in mice, albeit not in rats, that the midline raphe nuclei express in IL-1 receptors [XREF_BIBR] and that IL-1beta- and LPS induced increase SERT activity and LPS induced immobility in the tail suspension test, a measure of behavioral despair, were abolished in IL-1R knockout mice [XREF_BIBR]."
29976854
reach
"IL-1beta (the main secreted isoform) is produced by microglia to act primarily on astrocytes, and we have reported previously that IL-1beta induces the production of secondary inflammatory mediators via binding to the IL-1 receptor type 1 (IL-1R1) and downstream activation of the extracellular signal regulated kinase (ERK1/2) in these cells."
20380881
sparser
"The aforementioned IL-1β subsequently activates IL-1R, which results in IL-1β auto stimulation and the further upregulation of IL-1-dependent chemokines and cytokines, such as IL-8 and IL-6."
35269467
reach
"While IL-1R1 can be stimulated by either of two cytokines, IL-1alpha or IL-1beta, it has been shown that IL-1beta plays a pivotal role in disease pathogenesis because it not only directly stimulates IL-1R1-dependent inflammatory signaling, but is also needed for the secretion of IL-1alpha from cells."
26195813
reach
"Our previous studies showed that hCG down-regulates the IL1B induced increase of IL1R2 and IL1RN in ESCs and amplifies the IL1B induced increase of IL1R1 XREF_BIBR."
23717664
sparser
"Although both IL-1α and IL-1β activate IL-1R1, we initially focused on the role of IL-1β."
37060806
reach
"In cultured pulmonary artery smooth muscle cells, IL-1β stimulated proliferation in an IL-1R and MyD88 dependent fashion (34)."
35096915
reach
"Constitutive IL-1β activation or lack of the IL-1R antagonist (IL-1Ra) in mice leads to the development of a human psoriasis-like Th17 cytokine profile in skin and an inflammatory phenotype that resem[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31837587
reach
"It has been shown that fibrosis is mainly induced by IL-1β and can be alleviated via antibodies or specific blockade of receptors IL-1R1 and IL-1β [40] ."
38071841
sparser
"Immune cell-derived cytokines, such as IL-1β activate the highly expressed IL-1R1 on neighboring insulin-producing β-cells."
35021057
reach
"The results show that young IL-1beta ko and IL-1r1ko mice showed an impairment in spatial memory task learning in the WM, suggesting that brain IL-1beta activates IL-1r1 to facilitate hippocampal spatial learning and memory in young mice."
29123474
reach
"In both young and old rats, IL-1beta induced a significant up-regulation of cerebellar IL-1Ra, IL-1RI, and TGF-beta1 mRNAs; hippocampal TGF-beta1 mRNA; hypothalamic IL-1beta, IL-1Ra, TGF-beta1, and gp 130 mRNAs; and midbrain IL-1beta and TGF-beta1 mRNAs."
10381547
sparser
"To investigate whether the substantial decrease in CB2 mRNA levels, observed exclusively with LPS treatment, was a consequence of potent IL-1R activation by IL-1β, we stimulated BV2 cells with LPS in the presence of the natural IL-1R antagonist IL-1RA."
39160534
reach
"Our findings indicate that : (i) IL-1beta directly affects the central nervous system and acts independently of infiltrating hematogenous cells; (ii) IL-1beta induces microglial activation but is not neurotoxic per se; (iii) IL-1beta enhances excitotoxic neuronal damage and microglial activation and (iv) IL-1ra, even when applied for only 4 h, reduces neuronal cell death and the number of microglial cells after excitotoxic damage."
15932594
reach
"Under basal conditions, mIL-1R1 is undetectable and microglia marginally respond to IL-1β.13 In vitro direct stimulation of microglia with LPS can drive IL-1R1 production but mIL-1R1 dependent products were not examined.20 Following LPS preconditioning, newly expressed mIL-1R1 allows microglia to directly respond to subsequent IL-1β administration via change of morphology and production of IL-1 family cytokines."
35282272
reach
"Given that mononuclear phagocytes can produce both the proinflammatory cytokines IL-1 alpha, IL-1 beta, and TNF-alpha as well as the suppressive cytokine IL-1ra, we proposed that IL-1 alpha, IL-1 beta, and TNF-alpha may induce IL-1ra from mononuclear phagocytes."
8179914
reach
"In particular, the systemic increase in IL-1beta concentration induces the activation of the neuronal IL-1R1 and the subsequent phosphorylation of NR2B subunit of NMDA receptor, which turn into NMDA mediated calcium influx into neurons [XREF_BIBR]."
| PMC
reach
"Activation of IL-1R1 by IL-1beta is also known to activate several signaling pathways that have been implicated in the antineurogenic effects of IL-1beta including JNK, GSK3beta and NF-kappaB."
26043079
reach
"Via the same pathways that IL-1β can induce depressive symptoms, IL-1ra can prevent these by competing with IL-1β for binding to IL-1 receptors, whilst not delivering a stimulating signal.It was unexp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17350781
reach
"In the canonical NF- k B signaling pathway IL-1β activates the IL-1β receptor (IL1R1) ultimately resulting in rapid and transient nuclear translocation of NF- k B, as schematically represented in Fig.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32966921
reach
"The stimulation of the inflammatory response after MI is significantly influenced by IL-1 signaling: apart from the discharge of IL-1α by necrotic cells, the upregulated type 1 IL-1 receptor (IL-1R1) in respondent leukocytes and fibroblasts is driven by de novo synthesis and activation of IL-1β [11]."
39375628
reach
"Despite IL-1RA mRNA inductions by IL-1beta, LEW/N hypothalamic cells exhibited higher constitutive and inducible mRNA levels of IL-1RII and IL-1RA compared to F344/N cells, suggesting that IL-1RII and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12576220
reach
"IL-1β derived from IMs activates a subset of IL-1R1–expressing AT2 cells through the HIF1α-mediated glycolytic pathway, transforming them into intermediate cells necessary for the differentiation of mature AT1 cells."
38579159
sparser
"Interleukin-1 receptor antagonist protein (IRAP) inhibits IL-1R activation by IL-1β [ xref , xref ] and IRAP has been effectively used in C6 cells to inhibit sCp gene expression induced by IL-1β [ xref ]."
25311416
reach
"If IL-1Ra is stimulated by IL-1beta in a linear manner, only two stable steady states would have been found."
25167060
reach
"Our previous studies showed that hCG down-regulates the IL1B induced increase in IL1R2 and IL1RN in human ESCs and further enhances the IL1B induced increase in IL1R1, thereby amplifying in vitro the release of angiogenic activity XREF_BIBR."
23717664
reach
"The simulated therapy slows down the loss of beta-cell mass (XREF_FIG, red crosses) because increased IL-1Ra drives IL-1beta into a less pathological regime."
25167060
sparser
"Primary sensory neurons particularly nociceptors in DRGs express IL-1 receptors (IL-1R), and activation of IL-1R by IL-1β can activate nociceptors rapidly to generate action potentials and elicit pain hypersensitivity via regulating sodium and potassium currents [ xref , xref ]."
28199982
reach
"Likewise, parallel cultures comparing IL-1R1 hi and IL-1R1 lo subpopulations of stage 3 iNK cells revealed that, whereas IL-15 alone maintained survival of both IL-1R1 hi and IL-1R1 lo subpopulations of stage 3 iNK cells in vitro, the addition of IL-1beta enhanced proliferation of the IL-1R1 hi, but not the IL-1R1 lo, subpopulation of stage 3 iNK cells (XREF_FIG)."
20620944
reach
"However, both TNF-R and IL-1R antagonists could significantly revert the NKCC1 immunoreactivity in astrocytes treated with TNF-alpha or IL-1beta."
24916922
sparser
"When released, IL-1β binds and activates IL1R1, which is expressed on most leukocytes as well as epithelial cells ( xref )."
33451983
reach
"SDF-1α, VEGFα, and IL-1β activate PI3Kγ downstream of G-protein coupled receptors (GPCRs) , receptor tyrosine kinases (RTKs), and Toll-like receptor (TLR) /IL-1R for chemokines, cytokines, and TLR lig[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30890304
reach
"Moreover, it was demonstrated that production of IL-1β via this platform induces IL-1R/MyD88 signaling to trigger nitric oxide (NO) production, enabling parasite killing and resistance to disease in C[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32298633
reach
"The induction of IL-1Ra by IL-1β was reduced in cells expressing SOCS-3 by 70% (fold induction IL-1Ra/Ppia) compared to primary cells transduced with a control luciferase expressing adenovirus (Exp 1:[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21237203
reach
"The induction of IL-1Ra by IL-1β was markedly reduced in cells expressing SOCS-3 compared to primary cells transduced with a control luciferase expressing adenovirus.In β-cell lines SOCS-3 has been sh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21237203
reach
"IL-1R1 signaling by IL-1beta is critical for the differentiation, expansion, and survival of Th17 cells, essential for defense against extracellular bacteria or fungi, yet implicated in autoimmune disease pathogenesis."
38974214
reach
"They showed that in MCF7 epithelial cells, IL-1β stimulation induces MyD88-dependent endocytosis of IL-1R1, and that this event is required for the redox-dependent NF-κB activation."
16723122
reach
"Although ACS (IRAP II (TM)) increased IL-1Ra and IGF-1 in equine cartilage explants treated with IL-1beta, there was no significant difference in MMP-3 production and proteoglycan loss or synthesis between ACS and serum treated samples suggesting minimal beneficial effects of ACS on cartilage matrix metabolism."
29713634
reach
"IL-1β activates the IL-1 receptor (IL-1R), which also signals through the MyD88 pathway, resulting in a positive feedback loop and amplified production of inflammatory mediators (12, 16)."
35069570
reach
"We demonstrate that activation of IL1R1 by IL-1beta (or IL-1alpha) may carry an important activation signal for innate immune responses, with the example of antimicrobial peptide production."
21261944
sparser
"In primary cultures of rat hippocampal neurons, IL-1R1 activation by IL-1β promotes the rapid ( within minutes ) MyD88-dependent phosphorylation of Src protein kinases ( Huang et al., 2011; Viviani et[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25445483
reach
"Thus, mature IL-1beta likely acts predominantly in a paracrine or endocrine manner, activating IL-1R signaling in effector cells such as CD4+ T-cells."
22206014
reach
"IL-1R can be activated by IL-1α and IL-1β within the inflamed comedones of acne patients [6]."
38731983
reach
"In terms of protein levels, E2 downregulated IL-1beta but upregulated IL-1ra and thereby decreased the IL-1beta and IL-1 ra ratio at 24h."
18455872
reach
"7 LPS and IL-1beta stimulate different receptors with similar intracellular signaling machinery (TLR4 and IL1R1, respectively) 40 therefore the simultaneous presence of these two molecules may additively increase the activity of their overlapping pathways."
25958832
reach
"Whereas IL-1beta treatment induced IL-17 producing MOG specific T cells in Il1r -/- mice, IKKi deficiency reduced the impact of IL-1 on MOG specific Th17 cells (XREF_FIG)."
23142783
sparser
"In the CNS, activation of IL-1R1 by IL-1β activates signaling pathways that modulate intracellular calcium [ xref ], expression of neurotransmitter receptors [ xref ], activation of cAMP response element-binding (CREB) [ xref ] and brain-derived neurotrophic factor (BDNF) expression [ xref ]."
22546005
reach
"S. aureus also activates the inflammasome (which has been shown to be in part mediated by S. aureus derived ATP, alpha-toxin, beta-hemolysin, gamma-hemolysin and PVL) that results in proteolytic processing and cellular release of IL-1beta, which activates the IL-1R to induce production of proinflammatory and antimicrobial immune responses against S. aureus."
31841134
reach
"However, we found that while an IL-1R antagonist peptide (IL-1RA) completely prevents NF-kappaB activation in hepatocytes treated with IL-1beta, the peptide has no effect on palmitate dependent NF-kappaB activation (XREF_FIG)."
22708078
reach
"Recently, we demonstrated that IL-1beta and PGF2 induce Il1r1 in cultured human myometrial smooth muscle cells (Verstraeten etal."
27440742
reach
"Aside from its ability to initiate further inflammatory cascades, IL-1β can also promote macrophage activation by activating IL-1R [26,27]."
36293333
reach
"IL-1R, which also functions through MyD88, is activated by the pro inflammatory cytokines IL-1beta and IL-18 and contributes to retinal degeneration."
25725353
eidos
"Meanwhile , IL-1 beta upregulated IL-1R1 through an autocrine mechanism ( He et al. 2016 ) ."
30536170
sparser
"Since we were unable to obtain IRAK1-deficient human fibroblasts, and since human IL-1β activates murine IL-1R ( xref ), we used synovial cells from WT and IRAK1KD mice to investigate the role of IRAK1 for release of neutrophil chemoattractants."
35801586
reach
"We show that as expected, the i.v. infusion of IL-1beta stimulated IL-1ra release."
10408981
reach
"It is of note that we could not detect IL-1β in the plasma, although our previous studies have shown that IL-1RA is markedly upregulated in the circulation—IL-1β is a strong inducer of IL-1RA."
20138139
reach
"One can argue that since IL-1alpha or IL-1beta stimulates IL-1Ra production, a lower level of IL-1Ra reflects less functional IL-1 due to inhibition of IL-1 signaling."
20422276
reach
"It has been well demonstrated that IL-1β and TNF-α, by activating their main receptors of IL-1R and TNFR1 in astrocytes, induce the activation of TRAF6/JNK signaling that maintain the persistence of NP [19]."
29190962
reach
"The IL-1β activation of neuronal IL-1R1 signaling can modulate intracellular Ca (Srinivasan et al., 2004), activation of postsynaptic receptors (Bertani et al., 2017) and BDNF-dependent synaptic signaling and function (Tong et al., 2012; Cai et al., 2014; Patterson, 2015)."
36438556
reach
"IL-1β activates the IL-1R and causes thereby a cascade of inflammatory events in the targets cells, such as neurons or glia."
26775823
eidos
"IL1beta enhanced proliferation through IL1R1 / CD121a because IL1 receptor antagonist ( IL1Ra ) completely inhibited it ."
35647352
reach
"IL-1beta activates the IL-1R that triggers a transcriptional program leading to the production of multiple inflammatory mediators, including IL-6 and TNF."
33176273
reach
"IL-1β and TNF-α enhanced the excitability of neurons by activating their specific receptors (IL-1R and TNFR), which are expressed on TG neurons, thus promoting inflammatory pain (Fig. 6)."
31501412
reach
"In addition, we now show that IL-1R activation by IL-1beta induces the IL-1alpha gene in pancreatic beta-cells (XREF_FIG C-G), suggesting a cytokine ' circuit ' that promotes overall beta-cell health (XREF_FIG G)."
33285301
reach
"Greater complexity is exhibited by the system, because the IL-1R signals exclusively through the adapter MyD88, and thus signaling pathways activated by IL-1beta parallel those activated by the TLRs."
19120490
reach
"Moreover, geniposide also inhibited cytokine release stimulated by TNF-α and IL-1β, which induced the inflammatory signaling cascade through binding to TNFR1 or IL-1R, respectively, in RAW 264.7 cells[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
24735815
reach
"The authors speculate that aging-related increases in IL-1β induce this shift in IL-1R arrangement."
34631420
reach
"Meanwhile, IL-1 beta upregulated IL-1R1 through an autocrine mechanism (He et al. 2016)."
30536170
reach
"IL1R is activated by IL1beta, a known sleep regulatory molecule [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
22387068
reach
"IL-1R is activated by IL-1β, elicits signal transduction, leads to the transcription of IL-8 gene."
38608448
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"LPS and both doses of IL-1beta increased IL-1ra (F = 6.500, df 7,29, p < 0.05)."
23840908
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"Nonetheless , as both IL-1alpha and IL-1beta activate IL-1Rs , these studies support the concept that activation of IL-1Rs regulate the expression and activity of hippocampal SERTs ."
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"In Q705K transduced cells, we have found the release of TNF to be a downstream event of IL-1R activation by IL-1beta, whereas the increased gene expression of TNF in these cells was not an IL-1R regulated event [XREF_BIBR]."
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"Stomach-specific expression of IL-1β in mice attracts and activates MDSCs through an IL-1 receptor (IL-1R)/NF-κB pathway, leading to spontaneous gastric inflammation and cancer (Tu et al., 2008)."
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"19 Recent evidence suggests that IL-1beta induces human IL-1R1 + Th17 cells to upregulate IFN-gamma production, thereby giving rise to Th17 and Th1 cells with a potentially pathogenic profile."
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"IL-1alpha and IL-1beta are also produced, which activate an IL-1R1 and MyD88-positive feedback loop in macrophages and IL-1R on other resident cells in the cornea."
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"Furthermore, disruption of IL-1beta signaling by caspase-1 KO specifically within bone marrow derived cells revealed that monocytes promoted anxiogenesis through stimulation of neurovascular IL-1R1 by IL-1beta."
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"Others have shown that IL-1R1 receptor activation by IL-1β increases the excitability of cultured neurons isolated from DRG, including via actions on voltage-gated sodium ion channels and potassium channels[ xref , xref , xref – xref ]."
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"We also show that P. aeruginosa activates NF-kappaB in macrophages through both the TIR containing adaptor protein (TIRAP)/MyD88 dependent and the TRIF dependent pathways, and that IL-1alpha and IL-1beta activation of IL-1R1 is an important feedback pathway in the host response to P. aeruginosa."
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"Next, we emphasize the role of IL-1β and HMGB1 in SE by providing the examples listed below:During recurrent seizures, endogenous “danger signals”, which are activated by potentially pathogenic damage, activate toll-like receptor 4 (TLR4) and brain cells release HMGB1, while IL-1β, released from neurons, glial cells, and brain endothelial cells during inflammasome activation, and macrophages expelled from the blood, activate IL-1R1 in epilepsy [112,116,117]."
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"IL-1β activates the IL-1R and causes thereby a cascade of inflammatory events in the targets cells, such as neurons or glia."
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"The first and best-studied cytokines in this family are IL-1alpha and IL-1beta, which induce similar pro-inflammatory reactions by interacting with the interleukin-1 type 1 receptor (IL-1R1) [38]."
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"Signaling of IL-1β was conventionally initiated by binding to interleukin-1 receptor (IL-1R) type 1 (IL-1R1), which presents three extra-cellular immunoglobulin binding domains and is associated with the highly homologous IL-1R accessory protein (IL-1RAcP or IL-1R3)."
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"During the response to seizures, IL-1Ra is induced by the IL-1β system several hours after IL-1β."
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"In our studies we have shown that IL-1beta promotes RIP of IL-1R1 and pharmacological antagonism of gamma-secretase activity attenuates IL-1beta responsiveness [12]."
19232518
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"Thus, we speculated that GSDMD in peripheral myeloid cells promotes neuroinflammation through the release of IL-1β, which activates IL-1R on microglial cells and changes their transcriptional profile."
37425058
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"By contrast, IL-1R is activated by IL-1alpha and IL-1beta, which are produced by host cells 15."
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"These include CXCL1/KC and probably CXCL2, 5, and 8, which recruit neutrophils from limbal capillaries to the corneal stroma, and IL-1alpha and IL-1beta, which then feedback to activate the IL-1R1 and MyD88 pathway in macrophages and most likely also in resident corneal epithelial cells and stromal fibroblasts."
20826748
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"IL-1β activates the IL-1R that triggers a transcriptional program leading to the production of multiple inflammatory mediators, including IL-6 and TNF."
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"Orbital fibroblasts, unlike those from skin, fail to express high levels of IL-1 receptor antagonist (IL-1ra) when treated with IL-1beta, leading to loss of modulation of IL-1 action."
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