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PSMD14 activates Neoplasms. 18 / 19
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"Together, these results indicated that the depletion of PSMD14 inhibited BC tumor growth in vitro and in vivo by targeting GPX4."
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"These findings suggest that PSMD14 could obviously induce EMT process through stabilizing SNAIL.Since SNAIL is reported to be involved in tumorigenesis and metastasis through EMT process [ 6–9 ], we p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Through classification of HCC patients from independent cohorts, in silico screening of DUBs expression and functional analyses, we demonstrated that the dubiquitinase POH1 deubiqutinates and stabilizes the TGF-β receptors and thereby potentiates tumor metastasis."
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"Additionally, our findings were confirmed in xenograft models, with PSMD14 depletion effectively inhibiting ERα positive tumor growth in vivo."
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"Apparently, knockdown of PSMD14 suppressed SNAIL-induce EMT and tumor metastasis."
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"Functional assays further demonstrated that PSMD14 knockdown significantly inhibited tumor growth and progression while enhancing cisplatin sensitivity."
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"PSMD14 may enhance tumor progression and resistance to anlotinib in osteosarcoma by regulating the PI3K/AKT/mTOR signaling pathway [32]."
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"Furthermore, we observed that PSMD14 promoted proliferation, migration, and invasion in vitro and tumor growth metastasis in vivo by stabilizing GRB2 protein."
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"Finally, PSMD14 knockdown in PC arrested tumor growth and lung metastasis."
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"Taken together, in this study, PSMD14 is characterized as an oncogenic protein to enhance tumor metastasis by regulating SNAIL stability in esophageal squamous cell carcinoma.Several studies proved th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore , the knockdown of POH1 inhibited tumor progression and induced apoptosis in mitochondria in vitro and RNAi of POH1 achieved similar results in vivo [ 173 ] ."
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"S1F) and transwell assays (Fig. 2, K and M) indicated that PSMD14 depletion exhibited less aggressive migratory and invasive potential.We further confirmed the tumor-promoting effect of PSMD14 by transfecting BT-549 and HCC1937 cells with a lentiviral vector containing the PSMD14 sequence or vector control, and the overexpression efficiency was examined by RT-qPCR (fig."
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"However, other mechanisms of PSMD14-mediated tumor progression, such as the immune microenvironment, remain elusive.NTF3 is a member of the nerve growth factor (NGF) family [49] and plays a critical role in neuronal differentiation, survival, neurite growth, and neurotransmitter synthesis by binding Trk receptors (high affinity) and receptor p75NTR (low affinity) [50–52]."
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"For example, PSMD14 enhances tumor progression and chemoresistance in patients with head and neck squamous cell carcinoma by cleaving ubiquitinated E2F1, which activates the E2F1/Akt/SOX2 signaling pathway to promote stemness [31]."
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"Emerging evidence has demonstrated that POH1 is upregulated in different types of malignancies, including hepatocarcinoma, esophageal squamous cell carcinoma, prostate carcinoma [ 25 ] and breast canc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Given that POH1 regulates the stability of Smad3, we propose that POH1 affects Smad3-mediated cellular function and promotes cell invasion and tumor metastasis in NCSLC."
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"Also, PSMD14 promoted HCC cell and tumor growth while inducing cell migration and tumor metastasis in in-vitro and in-vivo by stabilizing GRB2 via deubiquitylation ( Lv et al., 2020 )."
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"Together, these results support a notion that PSMD14 promotes myeloma cell proliferation and colony formation and represses myeloma cell apoptosis, and that it does so through transcription activation[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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