IndraLab

Statements


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"A20 also inhibited TRIF-, but not its downstream signaling components TBK1-, IKKbeta-, and IKKepsilon-mediated activation of ISRE and NF-kappaB and IFN-beta promoter."

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"Taken together, these observations suggest that A20 inhibits a TRIF- and RIPK3-dependent step in NLRP3 inflammasome activation that is distinct from TLR-triggered transcription."