IndraLab

Statements

TNFAIP3 inhibits TICAM2. 3 / 3
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"In reporter gene assays, A20 could potently inhibit TRIF-, but not TBK1-, IKKε- and IKKβ-induced activation of ISRE, NF-κB and IFN-β promoter ( Fig. 2 )."
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"A20 may also inhibit TRIF, an essential adapter protein of the TLR3-pathway, efficiently inhibiting IFN β gene expression ( Wang et al., 2004 )."
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"Taken together, these observations suggest that A20 inhibits a TRIF- and RIPK3-dependent step in NLRP3 inflammasome activation that is distinct from TLR-triggered transcription."
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