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BAP1 activates cell cycle. 9 / 9
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"Compared with controls, BAP1 loss was associated with a decreased number of smaller colonies ( p < 0.01) ( Fig. 3 B and D), indicating that BAP1 knockdown indeed inhibits anchorage-independent growth [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The E2F1 targets pathway was involved in the BAP1-mediated cell cycle progression of uveal melanoma cells [3]."
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"BAP1 loss causes transient cell cycle inhibition."
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"Moreover, RNA mediated depletion of BAP1 promoted cell cycle G1-S progression XREF_BIBR."
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"In sharp contrast, RNA interference mediated depletion of BAP1 induced cell cycle progression defects and inhibited cell proliferation in vitro XREF_BIBR XREF_BIBR, suggesting that BAP1 may have dual roles in cancer development."
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"Downregulation of BAP1 promotes proliferation, cell cycle progression, and invasion of ICC in vitro."
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"In functional experiments, BAP1 has been shown to suppress lung cancer tumorigenesis in athymic nude mice, promote the cell cycle and induce both apoptosis and necrosis."
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"A previous study has shown that BAP1 accelerates the G(1)-S checkpoint process by influencing the cell cycle and induces cell death through processes characterized by apoptosis and necrosis (19)."
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"In the spleen, Bap1 deletion reduced cell cycle proteins (p = 6.2e-20), consistent with pancytopenia often observed in myelodysplastic disorders (XREF_FIG)."
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