IndraLab

Statements

eidos
"USP4 was found to enhance DNA double-strand breaks repairment , DNA-end resection and homologous recombination via a conversed and specific domain to form a complex with CtIP and the MRE11-RAD50-NBS1 complex which can be abrogated by USP4 auto-deubiquitination on several specific cysteine residues ."
32669974
reach
"USP4 promotes DNA-end resection and HR by recruiting CtIP to DSB sites [94,95]."
28764946
reach
"USP4 auto-deubiquitination stabilizes its interaction with CtIP and MRN complex and stimulates HR repair [151,152]."
28552167
reach
"So far, however, we only have a relatively limited understanding of the DDR roles for deubiquitylation enzymes (DUBs), which mediate the processing of DNA end resection.In this study, we show that the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26387952