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Propofol activates KCNMA1. 3 / 3
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"Therefore, propofol-induced activation of the BK channel causes hyperpolarization, which may further affect the SMC potential via gap junction communication, and it is well recognized as a potential mechanism of vascular relaxation."
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"The whole-cell patch clamp assay is a technique that is only performed on single SMCs, but in theory, the propofol-induced activation of the BK channel may lead to transfer of the hyperpolarization information, which further results in the fast and synchronized relaxation of the MA.Due to the long artery span and alterations in blood flow intensity, regulation of the blood pressure by the microcirculation is required along the full length of the blood vessels."
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"Interestingly, another intravenous anesthetic (propofol) activates the BK channel to relax coronary arteries [XREF_BIBR]."
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