IndraLab

Statements

BAP1 inhibits Death. 3 / 3
| 3
reach
"Recent evidence highlights that BAP1 suppresses metabolic stress-induced death in cancer cells (70,71)."
33446574
reach
"We discovered that fetal loss of the epigenetic regulator Bap1 in the ENS lineage caused severe postnatal bowel dysfunction and early death in Tyrosinase-Cre Bap1 fl/fl mice."
38690732
reach
"For example, differentiation to mature neurons and glia could require antagonism of PRC-mediated transcriptional repression.We were thus intrigued by our serendipitous discovery that Bap1 deletion in ENS lineages caused profound bowel dysfunction and early death in mice, mimicking human nCIPO or HSCR physiology."
38690732