IndraLab

Statements


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"The carboxyl-terminal domain of VCAN interacts with the β1 integrin of glioma cells, activating focal adhesion kinase (FAK), promoting cell adhesion and preventing apoptosis [ xref ]."

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"The strongest interaction was found between SPP1 + macrophages and FAP + fibroblasts in the TME of NSCLC, which is mediated by the VCAN-ITGB1 ligand-receptor pair."

sparser
"NicheNet analysis implicates the VCANITGB1 ligand–receptor axis in this interaction, and spatial transcriptomics confirms its role in establishing an immune-excluded architecture around the tumor core ( xref )."

No evidence text available

sparser
"The interaction analyses indicate that the ECM and adhesion related interaction between MSC and other stromal cells reduced during aging (FN1-ITGA5, FBN1-ITGB1, FBLN1-ITGB1, COL1A1-ITGA11, VCAN-ITGB1) (Supplementary Fig.  xref )."

sparser
"Nichnet analysis showed VCAN-ITGB1 ligand-receptor axis mediating this cellular interaction."