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COPS6 inhibits CTNNB1. 6 / 6
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"The CSN6 knockdown mediated beta-catenin destabilization translated into beta-catenin 's reduced transcriptional activity, as evidenced by qRT-PCR findings showing diminished expression of beta-cateni[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, we demonstrate that CSN6 enhances beta-catenin stability and that the CSN6 associated protein beta-Trcp negatively regulates beta-catenin stability."
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"As expected, we found that the beta-catenin level decreased and that of beta-Trcp increased when cells were treated with CSN6-shRNA (CSN6 knockdown) (Fig XREF_FIG A and B)."
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"CSN6 overexpression reduced the turnover rate of beta-catenin and increased the turnover rate of beta-Trcp."
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"CSN6 overexpression reduced the turnover rate of beta-catenin and increased the turnover rate of beta-Trcp (XREF_FIG)."
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"The CSN6 knockdown mediated beta-catenin destabilization translated into beta-catenin 's reduced transcriptional activity, as evidenced by qRT-PCR findings showing diminished expression of beta-catenin target genes, including myc, cyclin D, and vascular endothelial growth factor (XREF_FIG)."
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