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USP10 inhibits KLF4. 2 / 2

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"Forced expression of USP10 remarkably increases KLF4 protein level by blocking the latter degradation, whereas the depletion of USP10 promotes KLF4 degradation and thus enhances tumorigenesis."

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"USP10 could also suppress lung tumorigenesis by regulating KLF4 stability but executed a tumor-promoting role in colorectal cancer by deubiquitinating NLRP7 [ 25 , 30 ]."

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IndraLab

Statements

USP10 inhibits KLF4. 2 / 2

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