IndraLab
Statements
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"Therefore, we generated two independent USP7 shRNAs that both efficiently downregulated USP7 expression (Figure 6F)."
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"The USP7 siRNA effectively reduced the expression of USP7 in both cells (Figure 2f), resulting in a significant reduction in MDM2 expression."
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"ELISA and Western blotting results indicated that USP7 overexpression significantly increased IL-1beta and IL-18 levels as well as the expression of USP7, NLRP3, GSDMD-N, active caspase-1, pro-caspase-1, MMP1, and MMP13, which was decreased by USP7 KD or apocynin (XREF_FIG)."
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"USP7 knockdown by shRNA reduced total cellular USP7 levels as well as USP7 promoter occupancy in p53 WT cells."
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"USP7 knockdown by shRNA reduced total cellular USP7 levels (XREF_FIG) as well as USP7 promoter occupancy in p53 wt cells (XREF_FIG)."
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"HAUSP knockdown not only reduced HAUSP expression level but also decreased nucleolin level (XREF_FIG)."
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"In the Jurkat cell line, we observed an interesting phenomenon that reduction in USP7 transcription caused by mono-allelic knock-out of USP7 did not reduce USP7 protein level."