IndraLab

Statements

USP7 increases the amount of USP7. 12 / 12
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"mmu_piR_037459 overexpression inhibited USP7 protein expression and mmu_piR_037459 knockdown increased USP7 protein expression ( Fig. 4 A and B)."
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"Therefore, we generated two independent USP7 shRNAs that both efficiently downregulated USP7 expression (Figure 6F)."
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"To elevate the expression of USP7, the coding sequence of USP7 was synthesized and cloned into pLVX-Puro plasmid (Clontech, Mountain View, USA)."
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"Overexpression of USP7 markedly promoted the expressions of USP7 and p53, whereas knockdown of USP7 decreased the expressions of USP7 and p53 ( Figure 3C)."
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"In the Jurkat cell line, we observed an interesting phenomenon that reduction in USP7 transcription caused by mono-allelic knock-out of USP7 did not reduce USP7 protein level."
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"The USP7 siRNA effectively reduced the expression of USP7 in both cells (Figure 2f), resulting in a significant reduction in MDM2 expression."
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"The underlying mechanism is that circ-DB can sequester miR-34a, stimulate expression of ubiquitin-specific peptidase 7 (USP7) and downstream factor cyclin A2 [ 81 ]."
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"USP7 knockdown by shRNA reduced total cellular USP7 levels (XREF_FIG) as well as USP7 promoter occupancy in p53 wt cells (XREF_FIG)."
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"In addition, USP7 depletion led to decreased expression of both MDM2 and EZH2 and an increase in p53 protein expression (Figure 6C,D), similar to that seen with pharmacologic inhibition of USP7 and further supporting a role for USP7 in NB tumor growth via to its effect on USP7 deubiquitinase activity, allowing for target protein degradation."
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"In further analysis, USP7 protein expression was decreased by si‐USP7 and increased by USP7 overexpression vector (Figure 4B)."
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"HAUSP knockdown not only reduced HAUSP expression level but also decreased nucleolin level (XREF_FIG)."
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"ELISA and Western blotting results indicated that USP7 overexpression significantly increased IL-1beta and IL-18 levels as well as the expression of USP7, NLRP3, GSDMD-N, active caspase-1, pro-caspase-1, MMP1, and MMP13, which was decreased by USP7 KD or apocynin (XREF_FIG)."
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