IndraLab

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USP20 binds CTNNB1. 4 / 4
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"Several ubiquitin-specific proteases (USPs), including USP2a [ xref ], USP39 [ xref ], USP47 [ xref ], and USP20 [ xref ] also directly bind to and deubiquitinate β-catenin in the cytoplasm, leading to elevated expression of Wnt target genes."
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"To further investigate the role of the USP20-β-catenin axis in cancers, they detected the protein and mRNA levels of USP20 and β-catenin in colon cancer and other cancer cell lines, including osteosarcoma, cervical, breast, ovarian, and colorectal cancer cell lines [ xref ]."
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No evidence text available
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"Thus, the USP20-β-catenin axis may be an emerging therapeutic target in colon cancer."
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