IndraLab

Statements

USP15 activates HMGB1. 5 / 5
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"Co-IP results of the endogenous proteins from B-CPAP cells and KTC-1 cells showed that USP15 could interact with HMGB1, supporting the functional cooperation of USP15 and HMGB1 (Figure 2D)."
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"USP15 modulates HMGB1 stability in a DUB-dependent manner."
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"Above all results demonstrated that USP15 increased HMGB1 stability in a DUB-dependent manner."
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"USP15 promotes the progression of papillary thyroid cancer by regulating HMGB1 stability through its deubiquitination."
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"To determine whether the functions of USP15 in regulating cell proliferation, migration, and invasion through the effects of HMGB1, we performed rescue experiments by overexpressing HMGB1 in USP15 knockdown cells or by knockdown HMGB1 in USP15 overexpression cells."
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