IndraLab

Statements

USP8 increases the amount of SMO. 3 / 3
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"UBPY may modulate Smo cell surface expression by attenuating Smo endocytosis and/or promoting Smo recycling (XREF_FIG)."
22253574
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"We also provide evidence that the non visual beta-arrestin Kurtz (Krz) acts in parallel with Smo ubiquitination to control Smo cell surface expression, and that the deubiquitinating enzyme UBPY promotes Smo cell surface expression by counteracting Smo ubiquitination."
22253574
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"Our explanation is that the increase in Smo levels that was induced by USP8 was still inhibited by Ptc, since we found that USP8 induced more severe overgrowth phenotypes in the ptc mutant background (XREF_FIG)."
22253573