IndraLab

Statements

GPX4 binds USP8. 6 / 6
| 1 5
sparser
"In keeping with this finding, USP8 interacted with GPX4 and removed the ubiquitination on GPX4 ( xref and)."
38598341
sparser
"Studies have shown that the knockdown or pharmacological inhibition of USP8 increases the sensitivity of colorectal cancer cells to ferroptosis and that USP8 interacts with GPX4 and prevents GPX4 protein degradation by affecting GPX4 deubiquitination [ xref ]."
40136465
reach
"USP8 interacts with and deubiquitinates GPX4, thereby preventing GPX4 protein degradation."
38598341
sparser
"The inhibition of the USP8–GPX4 axis promoted ferroptosis and enhanced CD8+ T-cell infiltration, thereby improving the efficacy of anti-PD-1 immunotherapy in CRC ( xref )."
40962058
sparser
"Importantly, targeting the USP8-GPX4 axis enhances the efficacy of anti-PD-1 immunotherapy in mouse tumor models, offering broad avenues for combinatorial therapeutic strategies in tumor immunotherapy."
38598341
sparser
"Together, our study elucidates the physiological role of USP8 in suppressing extensive lipid peroxidation and ferroptosis via stabilizing GPX4 and highlights targeting the USP8-GPX4 axis as a potential strategy to enhance the efficacy of anti-PD-1 immunotherapy."
38598341