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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

STAMBP activates IL1B. 2 / 2

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"We hypothesized that targeting of STAMBP DUB activity to destabilize NALP7 will decrease NALP7 inflammasome activity, namely secretion of mature IL-1beta."

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"Our finding that STAMBP knockdown reduces IL-1beta secretion suggest that much of this effect is from NALP7 destabilization, but further study is needed to determine if endosomal trafficking and interaction with STAMBP is a required step for inflammasome assembly."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...