IndraLab

Statements

STAMBP activates IL1B. 2 / 2

| 2

reach

"We hypothesized that targeting of STAMBP DUB activity to destabilize NALP7 will decrease NALP7 inflammasome activity, namely secretion of mature IL-1beta."

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➶

reach

"Our finding that STAMBP knockdown reduces IL-1beta secretion suggest that much of this effect is from NALP7 destabilization, but further study is needed to determine if endosomal trafficking and interaction with STAMBP is a required step for inflammasome assembly."

28492230

INDRA sources:

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IndraLab

Statements

STAMBP activates IL1B. 2 / 2

INDRA sources:

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