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UCHL1 increases the amount of AKT. 3 / 3
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"Consistent with our prior reports27, Fig. 7C demonstrates that UCHL1 silencing in human lung ECs reduces Akt levels and Akt473 phosphorylation."
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"We also observed that silencing of UCH-L1 decreased the phosphorylation level of Akt and PCNA in the xenograft experiments."
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"Previous studies have shown that UCHL1 leads to the activation of AKT, as evidenced by the upregulation of phosphorylated AKT.39–43 Likewise, our results showed that UCHL1 deficiency decreased the phosphorylation level of AKT in macrophages."
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