IndraLab

Statements


OTUB1 increases the amount of FOXM1. 5 / 5
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"The results showed that in MCF-7 cells OTUB1 depletion culminated in the downregulation of FOXM1, but not vice versa (XREF_FIG), suggesting that OTUB1 positively regulates FOXM1 expression."

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"To investigate the idea that OTUB1 modulates FOXM1 expression further, we examined the effects of silencing OTUB1 and FOXM1 on the expression of endogenous OTUB1 and FOXM1 protein in MCF-7 cells."

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"Mechanistically, knockdown of OTUB1 down-regulated FOXM1 expression by promoting its ubiquitination."

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"Given our previous finding that genotoxic agents cause FOXM1 SUMOylation, ubiquitination and degradation, these observations led us to hypothesize that OTUB1 promotes FOXM1 expression at the posttranslational level to potentiate genotoxic agent resistance."

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"FOXM1 expression reduced upon OTUB1 depletion by siRNA and increased with OTUB1 overexpression in MCF-7 cells, arguing that OTUB1 positively regulates FOXM1 expression."