IndraLab

Statements

OTUD5 activates MTOR. 4 / 4
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"Interestingly, OTUD5 positively regulates the mTOR pathway by removing ubiquitin molecules from the ubiquitin ligases β-TrCP1 and RNF186, thereby stabilizing both proteins."
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"OTUD5 knockdown inhibited the cell proliferation, and OTUD5 positively regulated the mTOR signaling pathway to promote cell proliferation."
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"In breast cancer and colon cancer, OTUD5 promotes carcinogenesis by regulating the mammalian target of rapamycin (mTOR) and Hippo signaling pathways [10,11,12]."
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"In bladder cancer, OTUD5 activates mechanistic target of rapamycin complex 1 (mTORC1) signalling by deubiquitinating and stabilizing ring finger protein 186 (RNF186) and promoting sestrin2 degradation [10]."
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