IndraLab

Statements

USP7 activates MDM4. 7 / 8
1 | 7
reach
"However, the ability of USP7 to prevent proteasomal degradation of HdmX (as well as Hdm2) was abolished following DNA damage."
20713061
reach
"Specifically, HAUSP inhibition drives the proteolysis of both negative regulators of p53, Mdm2 and Mdmx, which subsequently decreases the ubiquitinated-p53forms leading to a total increase in p53 protein levels."
29616860
reach
"Because HAUSP rescues Hdm2-mediated degradation of Hdmx, we wondered whether an increase in HAUSP expression would also prevent the degradation of Hdmx after DNA damage."
15916963
reach
"In cases where p53 is of the wild type (Wt-p53) in tumors, inhibiting USP7 promotes the degradation of MDM2/MDMX, leading to the activation of p53 signaling."
39880128
reach
"It could be hypothesized that not the decrease in HAUSP activity triggers the degradation of Hdmx but rather an increase in Hdm2 activity."
15916963
reach
"USP7 inhibition promotes the degradation of MDM2 and MDMX, activates the p53 signaling, and causes cell cycle arrest and apoptosis, making USP7 a potential target for cancer therapy."
32300595
reach
"These results indicate that HAUSP rescues Hdmx from degradation by Hdm2 and that HAUSP increases the endogenous protein levels of Hdmx.To investigate a putative function for endogenous HAUSP in the re[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15916963