IndraLab

Statements

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"In support of the role of autophagy in modulating response to treatment, the administration of hydroxychloroquine (HCQ), an autophagy inhibitor, was found to enhance anti-cancer activity of the histone deacetylase inhibitor, vorinostat (VOR), in preclinical models and early phase clinical studies of metastatic CRC [XREF_BIBR]."
| PMC
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"Preclinical models showed that HCQ enhances the antineoplastic activity of vorinostat (VOR) in colorectal cancer (CRC) cells [18]."
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"For example, HCQ has been reported to enhance the anti-cancer activity of the histone deacetylase inhibitor, vorinostat (VOR), in pre-clinical models and early phase clinical studies of metastatic colorectal cancer (mCRC) [75]."
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"Hydroxychloroquine (HCQ) enhances the anti-cancer activity of the histone deacetylase inhibitor, vorinostat (VOR), in pre-clinical models and early phase clinical studies of metastatic colorectal cancer (mCRC)."
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"It has been hypothesized that hydroxychloroquine could potentiate the activity of vorinostat through inhibition of autophagy, and this combination has been evaluated for safety in the oncology setting [XREF_BIBR]."
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"For example, HCQ has been reported to enhance the anticancer activity of the histone deacetylase inhibitor, vorinostat (VOR), in pre-clinical models and early phase clinical studies of metastatic colorectal cancer (mCRC) (Patel et al., 2016)."
| DOI