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USP22 activates Wnt/β-catenin. 5 / 5
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"Silencing USP22 can inhibit the Wnt/β-catenin pathway to reduce cell stemness and enhance the sensitivity of PC cells to cisplatin."
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"USP22 was found to promote β-catenin nuclear localization, thus increasing the activity of the Wnt/β-catenin pathway in cancer cells [41] ."
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"Besides that, our findings also verified that USP22 interacted with ADAM9 to mediate the activation of Wnt/β-catenin pathway in trophoblast cells.DUBs consists of five families: USPs, UCHs, OTUs, JAMM[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, SOX9 was also reported to bind the promoter of ubiquitin-specific peptidase 22 (USP22), a deubiquitinating enzyme, promote its transcription, and activate the Wnt/β-catenin pathway (Miao et al., 2022)."
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"Silencing USP22 inhibited the Wnt/β-catenin pathway."
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