IndraLab

Statements

CDK11p46 kinase phosphorylates EIF3F. 3 / 3
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rlimsp
"After prolonged stress-induced apoptosis, Mss4 is downregulated, leading to a release of eIF3f, which is phosphorylated by the CDK11p46 kinase and the translation initiation results inhibite."
23354061
rlimsp
"If a certain threshold of stress is crossed, Mss4 is downregulated, leading to a release of eIF3f, which can now be phosphorylated by the caspase-activated CDK11p46 kinase, incorporated into the eIF3 protein compound, which in turn results in inhibition of translation and induction of apoptosis (right picture."
22495352
rlimsp
"Furthermore, during apoptosis eIF3f has been shown to be bound and phosphorylated by CDK11p46 kinase."
22495352