IndraLab

Statements

USP8 deubiquitinates BRIT1. 6 / 6
| 6
reach
"Together these results demonstrated that the UBC but not the BIR domain is required for BRUCE to promote USP8 deubiquitination of BRIT1 in response to IR exposure."
26683461
reach
"Deubiquitination of BRIT1 by BRUCE dependent USP8 is an intermediate step between the complex formation and BRIT1 recruitment to DSB."
26683461
reach
"BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1."
25733871
reach
"BRIT1 is deubiquitylated and stabilized by USP8 with the help of the scaffold protein BRUCE, tightly regulating the action of BRIT1 at damaged sites."
27516771
reach
"Following DSB induction, BRUCE promotes USP8 mediated deubiquitination of BRIT1, a prerequisite for BRIT1 to be released from the complex and recruited to DSB by binding to gamma-H2AX."
26683461
reach
"Following exposure to IR, USP8 promotes BRIT1 deubiquitination in BRUCE dependent manner, leading to dissociation of BRIT1 from the platform and consequent recruitment of it to the DSB sites by binding to gamma-H2AX."
26683461