IndraLab

Statements

YOD1 decreases the amount of NLRP3. 7 / 7
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"YOD1 attenuated NLRP3 expression and inflammation activation in vitro and in vivo."
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"Intriguingly, overexpression of YOD1 greatly decreased NLRP3 protein level rather than NLRP3 mRNA expression in MRSA-infected PMs, suggesting that YOD1 regulated NLRP3 expression through post-translational modifications (Fig. S4A–C)."
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"However, the protein level of NLRP3 induced by MRSA decreased in a dosage-dependent after Yod1 was transfected into macrophages, whereas Yod1(C155S) did not affect NLRP3 expression (Fig. 7D, E), indicating that YOD1 suppressed NLRP3 expression through its enzymatic activity."
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"Furthermore, the loss of Yod1 expression enhanced the expression of NLRP3 in vitro and in vivo."
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"Conversely, overexpression of YOD1 decreased the expression of NLRP3 in MRSA-infected PMs."
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"YOD1 interacted with NLRP3 to remove K33-linked ubiquitination of NLRP3 based on its deubiquitinating enzyme activity and specifically inhibited expression of NLRP3 as well as activation of NLRP3 inflammasome."
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"Furthermore, ectopic expression of Yod1 in PMs inhibited the expression of NLRP3, while the mutant did not."
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