IndraLab

Statements

USP28 binds CHEK2. 5 / 5
| 4 1
sparser
"It was previously shown that USP28 interacts with CHK2 [ xref ]."
| PMC
reach
"USP28 forms a complex with PIRH2 and CHK2 and antagonizes PIRH2 mediated polyubiquitylation and proteasomal degradation of CHK2 [XREF_BIBR]."
28031783
reach
"Similar to FBXW7, USP28 forms a complex with PIRH2 and CHK2, thus antagonizing the ubiquitination of CHK2 by PIRH2.The protein PIRH2 (also called RCHY1) is a promising candidate for maintaining the previously demonstrated USP28 “piggyback” model."
| PMC
reach
"We show that the deubiquitylating enzyme USP28 forms a complex with PIRH2 and CHK2 and antagonizes PIRH2 mediated polyubiquitylation and proteasomal degradation of CHK2."
23449389
reach
"USP28 forms a complex with PIRH2 and CHK2 and counteracts the negative regulation of PIRH2 on CHK2 21."
29415985