IndraLab

Statements

MALT1 inhibits TNFAIP3. 10 / 10
| 1 9
sparser
"However, MALT1 inactivates A20 by cleavage after arginine 439 to disrupt its inhibitory effect on NF-κB ( xref ) ( xref )."
22435550
sparser
"MALT1 proteolytically cleaves and inactivates A20 as well as CYLD, two negative regulators of NF-κB signaling ( xref , xref )."
22224767
eidos
"For example , following TCR stimulation , A20 is degraded by paracaspase MALT1 [ 79 , 80 ] ."
| PMC
sparser
"Even though the exact position has not been mapped, the data suggest that MALT1 also inactivates murine A20."
38863711
sparser
"Thus, MALT1 and A20 are part of an auto-regulatory feedback loop, in which MALT1 cleaves and inactivates A20, which in turn together with ABIN-1 counteracts MALT1 protease activation."
35099607
sparser
"Interestingly, MALT1 in turn cleaves and inactivates A20 to ensure optimal signal transduction [66] ."
30514565
sparser
"MALT1 protease exerts a crucial function for sustaining CBM signaling, because MALT1 continually cleaves and inactivates A20, which impairs the negative regulatory effect of A20 on the CBM complex."
35099607
sparser
"Firstly, Malt1 directly cleaves and inactivates A20, a negative regulator of the antigen receptor-to-NF-κB pathway."
19772915
sparser
"Because A20 and CYLD are deubiquitinases targeting K63-type polyubiquitin chains and are responsible for suppressing NF-κB activation, inactivation of A20 and CYLD by Malt1 is expected to potentiate N[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23706741
sparser
"Although MALT1 inactivates A20 by protease activity-mediated cleavage, it seems to be dispensable for initial IKK/NF-κB activation by TCR stimulation ( Coornaert et al., 2008 )."
25175772