IndraLab

Statements

MALT1 inhibits TNFAIP3. 8 / 8
| 1 7
sparser
"MALT1 proteolytically cleaves and inactivates A20 as well as CYLD, two negative regulators of NF-κB signaling ( xref , xref )."
22224767
eidos
"For example , following TCR stimulation , A20 is degraded by paracaspase MALT1 [ 79 , 80 ] ."
| PMC
sparser
"Although MALT1 inactivates A20 by protease activity-mediated cleavage, it seems to be dispensable for initial IKK/NF-κB activation by TCR stimulation ( Coornaert et al., 2008 )."
25175772
sparser
"Firstly, Malt1 directly cleaves and inactivates A20, a negative regulator of the antigen receptor-to-NF-kappaB pathway."
19772915
sparser
"MALT1 protease exerts a crucial function for sustaining CBM signaling, because MALT1 continually cleaves and inactivates A20, which impairs the negative regulatory effect of A20 on the CBM complex."
35099607
sparser
"Firstly, Malt1 directly cleaves and inactivates A20, a negative regulator of the antigen receptor-to-NF-κB pathway."
19772915
sparser
"Thus, MALT1 and A20 are part of an auto-regulatory feedback loop, in which MALT1 cleaves and inactivates A20, which in turn together with ABIN-1 counteracts MALT1 protease activation."
35099607
sparser
"However, MALT1 inactivates A20 by cleavage after arginine 439 to disrupt its inhibitory effect on NF-κB ( xref ) ( xref )."
22435550