IndraLab

Statements

BAP1 binds KEAP1. 9 / 9
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sparser
"Alternatively, it can be speculated that BAP1 might competitively bind to KEAP1 at the BTB domain with unknown protein(s) affecting the stability of KEAP1."
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sparser
"In order to identify the domains of BAP1 that interact with KEAP1, we generated FLAG-BAP1 mutant plasmids lacking individual domains (FLAG-BAP1ΔCD, FLAG-BAP1ΔCC1, FLAG-BAP1ΔCL, FLAG-BAP1ΔCC2, FLAG-BAP1ΔULD, and FLAG-BAP1ΔCTE)."
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reach
"Tumor suppressors, such as p53, BAP1, Kelch-like ECH associated protein 1 (KEAP1), function through induction of ferroptosis mainly via regulating SLC7A11 expression [4], [5], [6]."
38933555
sparser
"Immunoprecipitation of endogenous BAP1 demonstrates that BAP1 interacts with endogenous KEAP1 ( xref D)."
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sparser
"In order to identify the domain of KEAP1 that interacts with BAP1, we generated pcDNA3-HA-KEAP1 mutant plasmids lacking individual domains (HA-KEAP1ΔBTB, HA-KEAP1ΔBACK, and HA-KEAP1ΔKELCH)."
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signor
"BAP1 directly binds to and deubiquitinates KEAP1. BAP1 stabilizes KEAP1 by binding to the BTB domain."
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sparser
"Our result shows that FLAG-BAP1 does not selectively bind to HA-KEAP1ΔBTB ( xref A, right panel), suggesting that BAP1 binds to the BTB domain of KEAP1."
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biogrid
No evidence text available
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biogrid
No evidence text available
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