IndraLab

Statements

Baicalin inhibits RELA. 12 / 12
| 1 11
reach
"Baicalin (Yan et al., 2019) can inhibit the protein expression of p‐p65 and p‐extracellular signal‐related kinase (ERK) and promote the expression of p‐AKT and p‐endothelial nitric oxide synthase in rats."
36271488
eidos
"We also detected the effect of baicalin on NF-kappaB p65 expression and found that baicalin can inhibit NF-kappaB p65 expression in PSCs after TGF-beta1 treatment ."
33536916
reach
"A study also showed that baicalin suppressed NF-kB p65 activation in rat synovium and human fibroblast-like synoviocytes [20] ."
28942223
reach
"In addition, baicalin (the main metabolite of BAI) suppresses LPS-induced activation of the TLR4/NF-κB p65 pathway and inflammation [66] ."
36842762
reach
"In RAW264.7 cells with CD14 knockdown, baicalin pretreatment did not prevent inflammatory responses and activation of MyD88 and NF-kappaB p65 pathway induced by high concentrations (1000mug/mL) of LPS."
32457419
reach
"However, baicalin (50 mg/kg and 100 mg/kg) suppressed the fluorescence intensity of NF-κBp65, so ethanol-induced NF-κBp65 translocation to the nucleus was inhibited by baicalin, which indicated that t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31734260
reach
"Interestingly, we observed very low expression level of RelA in TAMs, and baicalin treatment could suppress RelA even in the presence of soluble TNF-alpha, a RelA activating cytokine (XREF_FIG)."
26492375
reach
"Baicalin treatment effectively inhibited the permanent NF-κB p65 activation and decreased the infarction area."
21093411
reach
"Consistent with other findings, our results showed that baicalin significantly reduced the activation of NF-κB p65."
39272057
reach
"The result suggested that baicalin can inhibit the activation of NF-kappaB p65 in the pancreas (XREF_FIG)."
33536916
reach
"Next, the RAW264.7 and BMDM cells were exposed to LPS with or without baicalin for 24 h to further confirm whether baicalin could inhibit macrophage SIRT1 and its downstream p65 NF-κB pathway in vitro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38762213
reach
"Additionally, a different study showed that baicalin pretreatment decreased LPS-induced activation of the MyD 88/NF-κB p65 pathway in RAW 264.7 cells and inhibited LPS-induced inflammatory responses, but not post-treatment [14]."
38617936