IndraLab

Statements

reach
"However, StA-IFN-1 and -4 (XREF_FIG, XREF_FIG) behaved as expected and were further examined by comparing their activity to the inhibitors TPCA-1, which inhibits the IFN induction pathway component IKKbeta, 15 and ruxolitinib, which inhibits IFN signaling pathway component Jak1 16 (XREF_FIG, XREF_FIG)."
27358388
tas
No evidence text available
21429745
sparser
"Consistent with a previous report xref , IKK2 inhibition by TPCA-1 did not cause ARPE-19 cell death even with TNFα induction ( xref )."
24489934
tas
No evidence text available
19035792
reach
"The NF-kappaB inhibitor [5-(p-fluorophenyl)-2-ureido] thiophene-3-carboxamide (TPCA-1), which inhibits IKKbeta, the kinase of IkappaBalpha (inhibitory protein of NF-kappaB), was used to prevent iron overload stimulated NF-kappaB changes in ESCs."
25500022
reach
"The sustained intracellular release of TPCA-1 enabled prolonged inhibition of IKKbeta and competitively inhibited TNF-alpha from activating NF-kappaB mediated pro inflammatory cytokine secretion."
27264972
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"Our results suggest that IKK2 inhibition by its specific inhibitor TPCA-1 is able to block laser induced CNV through the IKK-NF-kappaB signaling pathway, and in turn, the transcription of its downstream target genes that promote neovascularization."
24489934
reach
"Our study demonstrated [XREF_BIBR] pleiotropy for TPCA-1, which inhibited not only IKK-beta [XREF_BIBR - XREF_BIBR], but also JAK1 kinase activity [XREF_BIBR]."
27533247
sparser
"Our results suggest that IKK2 inhibition by its specific inhibitor TPCA-1 is able to block laser-induced CNV through the IKK-NF-κB signaling pathway, and in turn, the transcription of its downstream target genes that promote neovascularization."
24489934
tas
No evidence text available
19285872
reach
"To determine if the rapid induction of apoptosis in macrophages and DC was NF-kappaB and IKK inhibition dependent and not an off-target effect of TAT-NBD, five additional NF-kappaB inhibitory compounds were tested : Compound A (CmpA) and TPCA-1, both of which inhibit IKKbeta; MG-132, which inhibits IkappaBalpha proteosomal degradation; and IKKiVII and Wedelolactone, which inhibit both IKKalpha and IKKbeta (see XREF_SUPPLEMENTARY)."
24406986
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"Although BMS and TPCA-1 are specific inhibitors of IKKbeta, they may have non target effects on TM expression."
25039491
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No evidence text available
18088098
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"Consistent with a previous report XREF_BIBR, IKK2 inhibition by TPCA-1 did not cause ARPE-19 cell death even with TNFalpha induction (XREF_FIG)."
24489934
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"TPCA-1 is an inhibitor of IKK2 and, thus, inhibits NF-kappaB signaling by preventing IkappaB degradation."
22246000
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"TPCA-1 is a selective inhibitor of human IkappaB kinase-2 (IKK-2) that inhibits production of pro inflammatory cytokines in vitro and in vivo and inhibits NF-kappaB nuclear localization XREF_BIBR, XREF_BIBR, XREF_BIBR."
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