IndraLab

Statements


KCNK2 inhibits IL6. 4 / 4
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"This study was designed to investigate the mechanisms by which Trek-1 decreases IL-6 secretion."

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"TREK-1 activation also decreased IL-6, IP-10, and CCL-2 secretion from primary AECs."

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"We found that Trek-1 deficiency decreased IL-6 secretion from mouse and human AECs at both transcriptional and translational levels."

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"We recently reported the expression of K2P channels in alveolar epithelial cells (AECs) and found that TNF-alpha stimulation of TREK-1 deficient AECs caused decreased IL-6 secretion but increased MCP-1 secretion in vitro [XREF_BIBR, XREF_BIBR]."