IndraLab

Statements

reach
"Reduced phosphorylation of TAK1, IκBα, and p65 was detected in OTUB1-deficient BMDCs upon stimulation with TgPFN (Fig. 2g), suggesting that OTUB1 is required for the full-fledged activation of NF-κB. To reinforce the assertion that OTUB1 promotes IL-12 production by increasing NF-κB activity, we studied the effect of IKK inhibition on TgPFN-induced cytokine production in OTUB1-sufficient and OTUB1-deficient BMDCs."
32024978
reach
"Therefore, we explored the impact of OTUB1 on DC-mediated IL-12 production during T. gondii infection."
32024978
reach
"Abolishment of NF-κB activity by the inhibitor dramatically reduced IL-12 production by both OTUB1-sufficient and OTUB1-deficient BMDCs and blunted the difference in IL-12 production between the two cell populations (Fig. 2h)."
32024978
reach
"Collectively, these results suggest that DC-specific OTUB1 contributes to parasite control in both acute and chronic toxoplasmosis by facilitating early IL-12 production in DCs, which is indispensable for eliciting the protective IFN-γ response."
32024978