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USP18 increases the amount of GSDMD. 2 / 2
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"Since GSDMD could be modified by ubiquitination, we determined whether USP18 modulated the ubiquitination level of GSDMD for its degradation."
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"We employed a model of endotoxic shock induced by Escherichia coli LPS and found that both USP18 WT and its enzymatic mutant C61A overexpression led to a significant reduction in GSDMD protein levels compared to control mice (Fig. 6B)."
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