IndraLab

Statements

BAP1 decreases the amount of TERT. 3 / 3
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"Chromosome 3p21.1-21.3 encoded sequences BAP1, but not SETD2 PARP-3 and PBRM1, repress hTERT transcription within 21NT cells."
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"Interestingly, literature data suggest that BAP1 could downregulate TERT expression (Linne et al., 2017)."
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"In conclusion, the results from the present study provide evidence to suggest that BAP1 and possibly PARP-3 repress hTERT transcription within breast cancer cells, which supports the hypothesis that multiple sequences on human chromosome 3p may be responsible for regulating hTERT transcription."
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