IndraLab

Statements

UCHL1 increases the amount of EGFR. 2 / 3
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"In addition, knockdown of UCHL1 increased EGFR polyubiquitination and decreased the EGFR level with or without EGF stimulation."
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"As epidermal growth factor receptor (EGFR) is a known suppressor of ER transcription [42] and UCHL1 may modulate EGFR expression [43], Chen et al. chose to explore a possible role for EGFR in modulation of ER expression by UCHL1 using EGFR overexpression or silencing experiments in ER− and ER+ cell lines [41, 42]."
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