IndraLab

Statements

UCHL1 increases the amount of EGFR. 4 / 5
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"Therefore, by maintaining intracellular KLF5 levels, UCHL1 supports EGFR expression transcriptionally."
38468288
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"In addition, knockdown of UCHL1 increased EGFR polyubiquitination and decreased the EGFR level with or without EGF stimulation."
32494592
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"As epidermal growth factor receptor (EGFR) is a known suppressor of ER transcription [42] and UCHL1 may modulate EGFR expression [43], Chen et al. chose to explore a possible role for EGFR in modulation of ER expression by UCHL1 using EGFR overexpression or silencing experiments in ER− and ER+ cell lines [41, 42]."
34497382
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"UCH-L1 overexpression upregulates the expression of EGFR, which in turn allows hyperactivity of the MAPK and PI3K/Akt signaling pathway to inhibit transcription of ERα, enhancing breast cancer invasion, metastasis and MDR (88)."
36844618