IndraLab

Statements

Ibuprofen inhibits RELA. 6 / 6
3 | 3
reach
"CSP-1103, but not ibuprofen, reduced the immunoreactivity of the RelA subunit in nuclear extracts, suggesting a reduced nuclear translocation (XREF_FIG A, B)."
28106772
reach
"It is known that nuclear transcription factor-kappa B (NF-κB), present in the cytoplasm of cells, plays a role in the transcription of genes associated with inflammation when activated.13,14 NF-κB p65 can be activated by SARS-CoV-2 through the activation of pattern recognition receptors (PRRs).15,16 In vitro studies have shown that ibuprofen can suppress NF-κB p65 activity, thereby reducing inflammation in COVID-19 patients.17 Patients with PD have a higher susceptibility to COVID-19 infection due to their advanced age."
38800597
ctd
No evidence text available
9890559
ctd
No evidence text available
15489888
ctd
No evidence text available
10602496
reach
"In the case of RELA, ibuprofen was also able to inhibit the increase in RELA by inflammatory cytokines in a significant manner (p < 0.05), confirming the anti-inflammatory properties of ibuprofen in our model.At the protein level, the expression of COX-1 and COX-2 was verified by Western blotting using samples of inflammation studies."
38675204