IndraLab

Statements


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"However, USP13, USP19, and USP22 inhibit virus-induced IFN production by removing K27-linked polyubiquitin chains from STING (40, 81) or TRIF (90)."

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"USP13 has been reported to deubiquitinate and stabilize STAT1 and promote interferon (IFN)-induced signalling XREF_BIBR."

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"Thus, USP13 positively regulates type I and type II IFN signaling by deubiquitinating and stabilizing STAT1 protein."