IndraLab

Statements

USP13 activates Interferon. 5 / 5
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"USP13 has been reported to deubiquitinate and stabilize STAT1 and promote interferon (IFN)-induced signalling XREF_BIBR."
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"USP13 is considered to promote IFN signaling and play an antiviral role by stabilizing STAT1 [55]."
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"Thus, USP13 positively regulates type I and type II IFN signaling by deubiquitinating and stabilizing STAT1 protein."
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"However, USP13, USP19, and USP22 inhibit virus-induced IFN production by removing K27-linked polyubiquitin chains from STING (40, 81) or TRIF (90)."
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"It has also been reported that USP13 promotes interferon signaling by stabilizing STAT1 [ 25 ] ."
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