IndraLab

Statements

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"In mammalian cells, knock-down of CSN3 or CSN8 in cultured cells can accelerate cell proliferation [XREF_BIBR, XREF_BIBR], whereas knock-down of CSN5 decreases cell proliferation and causes cell senescence [XREF_BIBR, XREF_BIBR]."
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"Depletion of Jab1 inhibits proliferation of pancreatic cancer cell lines."
17027978
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"Knockdown of either CSN2 or CSN5 dramatically diminished cell proliferation, followed by loss of cell viability."
19400951
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"Knockdown of CSN5 inhibits the proliferation of human tumor cells XREF_BIBR XREF_BIBR, suggesting that overexpression of CSN5 not only serves as a marker of malignant transformation, but also actually contributes to tumor cell proliferation."
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"Depletion of Jab1 by siRNA increases accumulation of p27 and induces cell-cycle arrest and inhibits cell proliferation in NPC cell lines."
22350412
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"We found that downregulation of CSN5 in Siha and Hela cells inhibited cell proliferation in vitro and in vivo, and the inhibitory effects were largely rescued by CSN5 overexpression."
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"In both, Bezielle inhibited cell proliferation, induced cell death and G2 cycle arrest by regulating the mediator proteins Jab1, p27 (Kip1) and p21 (Cip1)."
21509784
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"Interestingly, siRNA mediated depletion of Jab1 inhibited cell proliferation and accelerated apoptotic cell death in NPC."
22350412
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"Knockdown of Jab1 inhibits proliferation and induces apoptosis in hepatocellular carcinoma cells 22."
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"Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer."
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"The results showed that downregulation of Jab1 significantly inhibited glioma cell proliferation, while overexpression of Jab1 promoted it."
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"Depletion of CSN5 suppressed cell proliferation, and induced premature senescence characterized by upregulation of senescence-associated-beta-galactosidase activity and increased expression of CDK inhibitors."
23127558
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"Knockdown of Jab1 and COPS5 results in the accumulation of p27 in cell nucleus, induces cell-cycle arrest and inhibits cell proliferation."
29535627
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"Further studies revealed that depletion of Jab1 inhibited cell proliferation, and induced premature senescence characterized by upregulation of senescence associated- beta-galactosidase activity and increased expression of CDK inhibitors."
29535627
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"(Phospho)-beta-catenin levels were found to be reduced following CSN5 knockdown and CSN5 promoted CRC cell proliferation but also apoptosis [30]."
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"Knockdown of Jab1 by small interfering RNA (siRNA) preferentially inhibited proliferation of HER-2 and neu-overexpressing breast cancer cells."
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"Interestingly, siRNA-mediated depletion of Jab1 inhibited cell proliferation and accelerated apoptotic cell death in NPC."
22350412