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BAP1 activates NPC. 3 / 3
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"In this study, we found that hypoxia-induced BAP1 enhances erastin-induced ferroptosis in NPC by stabilizing H2A.Studies have shown that many tumor cells under a hypoxic microenvironment are less sensitive to chemotherapeutic agents because these agents typically require oxygen for maximum activity [12]."
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"Hypoxia-induced BAP1 enhances erastin-induced ferroptosis in NPC by stabilizing H2A."
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"Ferroptosis inducers targeting BAP1 may be an effective way to reduce drug resistance in NPC, especially in the hypoxic microenvironment.In conclusion, our study initially validated that hypoxia-induced BAP1 enhanced erastin-induced ferroptosis in NPC by stabilizing H2A (Fig. 7)."
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