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Glutathione inhibits JAK1. 2 / 2
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"We assessed whether GSH depletion inhibits JAK1 activation induced by LIF, which is the initiating step in IL-6-type cytokine signaling."
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"Therefore, the present study was undertaken to directly test the hypothesis that JAK1 signaling by the IL-6-type cytokines in cardiac myocytes is impaired by glutathione (GSH) depletion, since this tripeptide is one of the major anti-oxidant molecules and redox-buffers in cells."
22939972