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SCN8A decreases the amount of RELA. 3 / 3
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"Furthermore, MED suppressed nuclear p65 expression in the aortic arch of HFD fed ApoE deficient mice (Additional file 2 : Figure XREF_FIG)."

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"XREF_FIG, MED significantly suppressed ox-LDL-induced IkappaB-alpha degradation, nuclear p65 expression, and the DNA binding activity of NF-kappaB at concentrations of 5 and 10muM in macrophages, which indicated that MED could inhibit the activation of NF-kappaB signaling."

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"The MED feeding significantly downregulated the expressions of the p50, p65, TNFalpha, IL-6, IFNalpha, IFNbeta, IL-12-p40, and CXCL2 genes compared to the ED mice (XREF_FIG)."